TREM2 Ectodomain Variant — Binding Optimized

🧬 Protein Design

Method

Rosetta Interface Design

Stability

88%

Binding (Kd)

120 nM

ΔG

-1.8 kcal/mol

MUTATIONS (5)

T96SK186RA192VH157YR62W

Sequence (82 aa)

MEPLRPPHLWAVLLLLGLRLQPRWAGSELQCKEVLKCTCNGSLECLQPRFQNSSKCSWWPAGRRCSCQVKGSVLGEPRPRPV

Interface residue optimization for enhanced Aβ oligomer recognition. Slight stability trade-off accepted for 6.5x binding improvement.

🔮 3D Structure — AlphaFold Q9NZC2 Click to load

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