TREM2 Stabilized Variant

🧬 Protein Design

Method

Rosetta

Stability

92%

Binding (Kd)

15.3 nM

MUTATIONS (2)

R47HR62H

Sequence (246 aa)

MEPLRPRLGLLLLLLPCLLLTGVPAQVTYQEEVTPQRNATTNKSALYPAGSQMPGETVSLPCQNTNTWNSDSEPKYVCKEPQVATLEVRRRLGHNGTQYFTPVAATGHMGLPLHVAGLYWYSGAASSAQPSGQLMNQTMAALATVTNRSFNHGTSYVHYSQTINRGDAALLTYDSQRLPELLNRNEFPFVTQKFVSTANTRTHIGDKAYKVDIQSEDVPTPDYSVNFTGYLFEGTFAEEAKSDLEQ

🔮 3D Structure — AlphaFold Q9NZC2 Click to load

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