TREM2 Ectodomain Variant — Stability Optimized

🧬 Protein Design

Method

Rosetta Relax

Stability

91%

Binding (Kd)

780 nM

ΔG

-2.3 kcal/mol

MUTATIONS (3)

T96SK186RA192V

Sequence (82 aa)

MEPLRPPHLWAVLLLLGLRLQPRWAGSELQCKEVLKCTCNGSLECLQPRFQNSSKCSWWPAGRRCSCQVKGSVLGEPRPRPV

Rosetta-guided mutations to improve thermostability without disrupting binding interface

🔮 3D Structure — AlphaFold Q9NZC2 Click to load

Rotate: click+drag | Zoom: scroll | Reset: right-click