TREM2 Ectodomain Variant — AlphaFold Base

🧬 Protein Design

Method

Alphafold

Stability

72%

Binding (Kd)

850 nM

pLDDT

0.89

Sequence (105 aa)

MEPLRGPHSLWALALCLLTSAGPGAQKVEVETTNPCRLDGRELSDTFYGPMTPEDQRTVSLGGDLGPGILSRHGLDSSVPPTTAEMQALGFRLEEASGPPCRESG

Wild-type ectodomain structure as baseline for optimization

🔮 3D Structure — AlphaFold Q9NZC2 Click to load

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