TREM2 Variant Design v2 — R186K/D87N Dual Mutant

🧬 Protein Design

Method

Rosettafold + Guided Mutagenesis

Stability

-45.1 kcal/mol

MUTATIONS (2)

R186KD87N

Sequence (212 aa)

MSLSRAAAQALWLWGGVAAELQTFKGPCDKKLSAERLAGGQQNGTLGLGNLTLWDPAEQLLNDLQHFMGVWKDIQLTQSSESVALRRSRSRAIVFQGLHFTVVTFQDKGLRSVTYQSVALQPDEYQGLTCYEDSPSAQKASQEAPMPNQTNTMASSPWSLVDLTHKVEEALNLISSQSIQEQLKQSNMGTMHFLSYQISSLNR186K_D87N

🔮 3D Structure — AlphaFold Q9NZC2 Click to load

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