TREM2 Variant Design v3 — R186K/D87N/T96I Triple Mutant (Optimized)

🧬 Protein Design

Method

Rosettafold + Bayesian Optimization + Md Simulation

Stability

-47.8 kcal/mol

MUTATIONS (3)

R186KD87NT96I

Sequence (217 aa)

MSLSRAAAQALWLWGGVAAELQTFKGPCDKKLSAERLAGGQQNGTLGLGNLTLWDPAEQLLNDLQHFMGVWKDIQLTQSSESVALRRSRSRAIVFQGLHFTVVTFQDKGLRSVTYQSVALQPDEYQGLTCYEDSPSAQKASQEAPMPNQTNTMASSPWSLVDLTHKVEEALNLISSQSIQEQLKQSNMGTMHFLSYQISSLNR186K_D87N_T96I

🔮 3D Structure — AlphaFold Q9NZC2 Click to load

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