➡ Upstream Target
alzheimers
✗ KILL CRITERIA
- or age-at-onset delay (>1 year) in GWAS meta-analysis of >50,000 AD cases vs. controls.
**EVIDENCE_KIND**: empirical
**RATIONALE**: This would directly contradict the premise that reducing tau is su
- and no enrichment for AD risk alleles among expression-increasing variants (permutation p >
- appears derived from MR/expression_qtl sources, but without colocalization, these relationships may reflect confounding, linkage, or downstream consequences of neurodegeneration rather than causal ups