➡
upstream target
Cellular senescence as upstream driver of tau pathology in AD
➡ Upstream Target
alzheimer
Identification:
MR+RCT+KO
✗ KILL CRITERIA
Senolytic intervention does not reduce tau aggregation
Senescence markers are downstream, not upstream, of tau pathology
p21/p53 knockout does not affect neurodegeneration phenotype
Convergence
3
Evidence Count
3
Falsification Wt
0.2
Effect Size
2.2
View on SciDEX ↗