➡
upstream target
ACE enhancement as upstream regulator of amyloid-beta clearance
➡ Upstream Target
alzheimer
Identification:
MR+RCT
✗ KILL CRITERIA
ACE activity has no correlation with Aβ clearance rates
ACE inhibitors do not affect amyloid burden in models
ACE genetic variants show no association with AD risk
Convergence
3
Evidence Count
3
Falsification Wt
0.15
Effect Size
1.9
View on SciDEX ↗