➡ Upstream Target
alzheimer's disease
✗ KILL CRITERIA
- AD risk or progression is unchanged in carriers of loss-of-function PINK1 variants after full GWAS correction
- PINK1 activator treatment fails to reduce phospho-tau or amyloid burden in ≥2 independent APP/PS1 mouse studies
- Mitochondrial membrane potential is normal in AD iPSC-derived neurons relative to age-matched controls