TREM2 (triggering receptor expressed on myeloid cells 2) as upstream causal target in Alzheimer's disease

➡ Upstream Target alzheimer's disease

Identification:MR

✗ KILL CRITERIA

TREM2 R47H carriers show no difference in AD progression rate from non-carriers in matched prospective cohort
TREM2 agonist antibody fails to shift microglia toward disease-associated states in two independent AD mouse models
TREM2 gene expression is not correlated with plaque burden or tau load in single-nucleus RNA-seq of AD cortex

Evidence Count

Falsification Wt

0.1

Effect Size

0.8