➡
upstream target
APOE4 as upstream causal driver in Alzheimer's disease
➡ Upstream Target
alzheimer
Identification:
MR+RCT+KO
✗ KILL CRITERIA
APOE4 KO mice show no AD-related phenotype
Human APOE4 variant has no effect on Aβ production in vitro
APOE4 lipid transport function is unrelated to amyloid clearance
Convergence
5
Evidence Count
5
Falsification Wt
0.1
Effect Size
4.2
View on SciDEX ↗