STING1 (stimulator of interferon response cGAMP interactor 1 (TMEM173)) as upstream causal target in Alzheimer's disease

➡ Upstream Target alzheimer's disease

Identification:KO

✗ KILL CRITERIA

cGAS-STING pathway markers (pTBK1, IFN-β) are not elevated in AD post-mortem microglia relative to age-matched controls
STING1 knockout fails to reduce microglial senescence or tau spreading in AD mouse models
Phase II STING antagonist trial shows no change in CSF neuroinflammation markers at 12 months

Evidence Count

Falsification Wt

0.1

Effect Size

0.85