➡ Upstream Target
Alzheimer's disease
Identification:MR + LLM_inferred
✗ KILL CRITERIA
- LRP1-dependent tau uptake blockade shows no effect on tau propagation in human iPSC neurons
- LRP1 agonist fails to reduce tau seeding in 12-month observational study
- Blood-brain barrier LRP1-mediated clearance mechanism is not replicable in human studies