➡ Upstream Target
Alzheimer's disease
✗ KILL CRITERIA
- TREM2 loss-of-function variants show no AD risk modulation in replication cohort (OR=1.0, p>0.05)
- Microglial TREM2 knockout in 5xFAD mice fails to alter amyloid plaque burden
- TREM2 agonist fails to reduce tau pathology in P301S tauopathy model