Basket Cells (Fast-Spiking PV+)

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Basket Cells (Fast-Spiking PV+)

<table class="infobox infobox-celltype">
<tr>
<th class="infobox-header" colspan="2">Basket Cells (Fast-Spiking PV+)</th>
</tr>
<tr>
<td class="label">Allen Atlas ID</td>
<td><a href="https://portal.brain-map.org/atlases-and-data/rnaseq" target="_blank">CS202210140_3492</a></td>
</tr>
<tr>
<td class="label">Lineage</td>
<td>Neuron > GABAergic > Cortical interneuron > Basket > PV+</td>
</tr>
<tr>
<td class="label">Markers</td>
<td>PVALB, GAD1, GAD2, SCN1A, KCNC1, CNTN2</td>
</tr>
<tr>
<td class="label">Brain Regions</td>
<td>Cerebral cortex, Hippocampus</td>
</tr>
<tr>
<td class="label">Disease Vulnerability</td>
<td>[Alzheimer's Disease](/diseases/alzheimers-disease), [Epilepsy](/diseases/epilepsy), Schizophrenia</td>
</tr>
</table>

Basket Cells (Fast-Spiking PV+)

Introduction

Basket Cells (Fast Spiking Pv+) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

Basket Cells (Fast-Spiking PV+) are a specialized cell type classified within the Neuron > GABAergic > Cortical interneuron > Basket > PV+ lineage. These cells are primarily found in Cerebral cortex, Hippocampus and are characterized by expression of marker genes including PVALB, GAD1, GAD2, SCN1A. They are selectively vulnerable in Alzheimer's Disease, Epilepsy, Schizophrenia.

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Basket Cells (Fast-Spiking PV+)

Introduction

Overview

Multi-Taxonomy Classification

Taxonomy Database Cross-References

| Taxonomy | ID | Name / Label |
|----------|----|---------------|
| Cell Ontology (CL) | [CL:0000118](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000118) | basket cell |

Morphology & Electrophysiology

Morphology: basket cell (source: Cell Ontology)
Morphology can be inferred from Cell Ontology classification

External Database Links

[Cell Ontology (CL:0000118)](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000118)
[OBO Foundry (CL:0000118)](http://purl.obolibrary.org/obo/CL_0000118)
[Allen Brain Cell Atlas](https://portal.brain-map.org/atlases-and-data/bkp/abc-atlas)
[CellxGene Census](https://cellxgene.cziscience.com/)
[Human Cell Atlas](https://www.humancellatlas.org/)

Taxonomy & Classification

| Database | ID | Name | Confidence |
|----------|----|------|------------|
| Cell Ontology | [CL:0000118](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000118) | basket cell | Exact |
| Cell Ontology | [CL:2000027](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_2000027) | cerebellar basket cell | Exact |

External Database Links

[Cell Ontology (CL:0000118)](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000118)
[OBO Foundry (CL:0000118)](http://purl.obolibrary.org/obo/CL_0000118)
[Allen Brain Cell Atlas](https://portal.brain-map.org/atlases-and-data/bkp/abc-atlas)
[CellxGene Census](https://cellxgene.cziscience.com/)

Morphology and Markers

Basket Cells (Fast-Spiking PV+) are identified by the expression of the following key marker genes:

PVALB
GAD1
GAD2
SCN1A
KCNC1
CNTN2

These markers are used for immunohistochemical identification and single-cell RNA sequencing classification, as catalogued in the [Allen Cell Type Atlas](https://portal.brain-map.org/atlases-and-data/rnaseq).

Normal Function

Basket Cells (Fast-Spiking PV+) play essential roles in neural circuits and brain function. They are found in the following brain regions:

Cerebral cortex
Hippocampus

Their normal functions include maintaining neural circuit integrity, signal processing, and contributing to the homeostasis of their local microenvironment.

Vulnerability in Disease

Basket Cells (Fast-Spiking PV+) show selective vulnerability in the following neurodegenerative conditions:

[Alzheimer's Disease](/diseases/alzheimers-disease)
Epilepsy
Schizophrenia

The selective vulnerability of these cells is an active area of research, with factors including metabolic demands, calcium handling, exposure to toxic protein aggregates, and cell-autonomous gene expression programs contributing to their susceptibility.

Transcriptomic Profile

Single-cell and single-nucleus RNA sequencing studies have revealed the transcriptomic signature of Basket Cells (Fast-Spiking PV+). Key differentially expressed genes from the Allen Cell Type Atlas and related datasets include the marker genes listed above. These transcriptomic profiles help identify subtypes and disease-associated gene expression changes.

Key Publications

[Fast-spiking basket cells in cortical circuits](https://doi.org/10.1038/s41583-022-00577-3). Nat Rev Neurosci, 2022.

External Links

Allen Cell Type Atlas: [https://portal.brain-map.org/atlases-and-data/rnaseq](https://portal.brain-map.org/atlases-and-data/rnaseq)
Allen Human Brain Atlas: [https://human.brain-map.org/](https://human.brain-map.org/)
[Cell Types Index](/cell-types)- [Diseases Index](/diseases)eases Index
[Mechanisms Index](/mechanisms) --

Background

The study of Basket Cells (Fast Spiking Pv+) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

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