Dorsal Motor Nucleus of the Vagus

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Dorsal Motor Nucleus of the Vagus

<table class="infobox infobox-celltype">
<tr>
<th class="infobox-header" colspan="2">Dorsal Motor Nucleus of the Vagus</th>
</tr>
<tr>
<td class="label">Allen Atlas ID</td>
<td><a href="https://portal.brain-map.org/atlases-and-data/rnaseq" target="_blank">CS202210140_3641</a></td>
</tr>
<tr>
<td class="label">Lineage</td>
<td>Neuron > Parasympathetic > Dorsal motor nucleus of vagus</td>
</tr>
<tr>
<td class="label">Markers</td>
<td>CHAT, SLC5A7, ISL1, SLC18A3, nNOS (NOS1)</td>
</tr>
<tr>
<td class="label">Brain Regions</td>
<td>Dorsal motor nucleus of vagus, Medulla oblongata</td>
</tr>
<tr>
<td class="label">Disease Vulnerability</td>
<td>[Parkinson's Disease](/diseases/parkinsons-disease), [Multiple System Atrophy](/diseases/multiple-system-atrophy), [Alzheimer's Disease](/diseases/alzheimers-disease)</td>
</tr>
</table>

Dorsal Motor Nucleus of the Vagus

Introduction

Dorsal Motor Nucleus Of The Vagus is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

...

Dorsal Motor Nucleus of the Vagus

Introduction

Overview

Mermaid diagram (expand to render)

Dorsal Motor Nucleus of the Vagus are a specialized cell type classified within the Neuron > Parasympathetic > Dorsal motor nucleus of vagus lineage. These cells are primarily found in Dorsal motor nucleus of vagus, Medulla oblongata and are characterized by expression of marker genes including CHAT, SLC5A7, ISL1, SLC18A3. They are selectively vulnerable in Parkinson's Disease, Multiple System Atrophy, Alzheimer's Disease.

Multi-Taxonomy Classification

Taxonomy Database Cross-References

| Taxonomy | ID | Name / Label |
|----------|----|---------------|
| Cell Ontology (CL) | [CL:0000100](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000100) | motor neuron |

Morphology & Electrophysiology

Morphology: motor neuron (source: Cell Ontology)
Morphology can be inferred from Cell Ontology classification

PanglaoDB Marker Cross-References

Unknown (PanglaoDB):

External Database Links

[Cell Ontology (CL:0000100)](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000100)
[OBO Foundry (CL:0000100)](http://purl.obolibrary.org/obo/CL_0000100)
[Allen Brain Cell Atlas](https://portal.brain-map.org/atlases-and-data/bkp/abc-atlas)
[CellxGene Census](https://cellxgene.cziscience.com/)
[Human Cell Atlas](https://www.humancellatlas.org/)
[PanglaoDB](https://panglaodb.se/)

Taxonomy & Classification

| Database | ID | Name | Confidence |
|----------|----|------|------------|
| Cell Ontology | [CL:0000100](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000100) | motor neuron | Medium |
| Cell Ontology | [CL:0002614](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0002614) | neuron of the substantia nigra | Medium |

PanglaoDB Marker Cross-References

Unknown (PanglaoDB):

External Database Links

[Cell Ontology (CL:0000100)](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000100)
[OBO Foundry (CL:0000100)](http://purl.obolibrary.org/obo/CL_0000100)
[Allen Brain Cell Atlas](https://portal.brain-map.org/atlases-and-data/bkp/abc-atlas)
[CellxGene Census](https://cellxgene.cziscience.com/)
[PanglaoDB](https://panglaodb.se/)

Morphology and Markers

Dorsal Motor Nucleus of the Vagus are identified by the expression of the following key marker genes:

CHAT
SLC5A7
ISL1
SLC18A3
nNOS (NOS1)

These markers are used for immunohistochemical identification and single-cell RNA sequencing classification, as catalogued in the [Allen Cell Type Atlas](https://portal.brain-map.org/atlases-and-data/rnaseq).

Normal Function

Dorsal Motor Nucleus of the Vagus play essential roles in neural circuits and brain function. They are found in the following brain regions:

Dorsal motor nucleus of vagus
Medulla oblongata

Their normal functions include maintaining neural circuit integrity, signal processing, and contributing to the homeostasis of their local microenvironment.

Vulnerability in Disease

Dorsal Motor Nucleus of the Vagus show selective vulnerability in the following neurodegenerative conditions:

[Parkinson's Disease](/diseases/parkinsons-disease)
[Multiple System Atrophy](/diseases/multiple-system-atrophy)
[Alzheimer's Disease](/diseases/alzheimers-disease)

The selective vulnerability of these cells is an active area of research, with factors including metabolic demands, calcium handling, exposure to toxic protein aggregates, and cell-autonomous gene expression programs contributing to their susceptibility.

Transcriptomic Profile

Single-cell and single-nucleus RNA sequencing studies have revealed the transcriptomic signature of Dorsal Motor Nucleus of the Vagus. Key differentially expressed genes from the Allen Cell Type Atlas and related datasets include the marker genes listed above. These transcriptomic profiles help identify subtypes and disease-associated gene expression changes.

Key Publications

[Dorsal vagal nucleus in autonomic dysfunction](https://doi.org/10.1038/s41583-022-00587-9). Nat Rev Neurosci, 2022.

External Links

Allen Cell Type Atlas: [https://portal.brain-map.org/atlases-and-data/rnaseq](https://portal.brain-map.org/atlases-and-data/rnaseq)
Allen Human Brain Atlas: [https://human.brain-map.org/](https://human.brain-map.org/)
[Cell Types Index](/cell-types)- [Diseases Index](/diseases)eases Index
[Mechanisms Index](/mechanisms) --

Background

The study of Dorsal Motor Nucleus Of The Vagus has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

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