Laterodorsal Tegmental (LDT) Cholinergic Neurons

📖 Wiki Page

cell584 wordssynced 2026-04-02

Laterodorsal Tegmental (LDT) Cholinergic Neurons

<table class="infobox infobox-celltype">
<tr>
<th class="infobox-header" colspan="2">Laterodorsal Tegmental (LDT) Cholinergic Neurons</th>
</tr>
<tr>
<td class="label">Allen Atlas ID</td>
<td><a href="https://portal.brain-map.org/atlases-and-data/rnaseq" target="_blank">CS202210140_3637</a></td>
</tr>
<tr>
<td class="label">Lineage</td>
<td>Neuron > Cholinergic > Laterodorsal tegmental</td>
</tr>
<tr>
<td class="label">Markers</td>
<td>CHAT, SLC5A7, SLC18A3, GABA, PENK</td>
</tr>
<tr>
<td class="label">Brain Regions</td>
<td>Laterodorsal tegmental nucleus</td>
</tr>
<tr>
<td class="label">Disease Vulnerability</td>
<td>[Parkinson's Disease](/diseases/parkinsons-disease), [Alzheimer's Disease](/diseases/alzheimers-disease), Narcolepsy</td>
</tr>
</table>

Laterodorsal Tegmental (LDT) Cholinergic Neurons

Introduction

Laterodorsal Tegmental (Ldt) Cholinergic Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

...

Laterodorsal Tegmental (LDT) Cholinergic Neurons

Introduction

Overview

Mermaid diagram (expand to render)

Laterodorsal Tegmental (LDT) Cholinergic Neurons are a specialized cell type classified within the Neuron > Cholinergic > Laterodorsal tegmental lineage. These cells are primarily found in Laterodorsal tegmental nucleus and are characterized by expression of marker genes including CHAT, SLC5A7, SLC18A3, GABA. They are selectively vulnerable in Parkinson's Disease, Alzheimer's Disease, Narcolepsy.

Multi-Taxonomy Classification

Taxonomy Database Cross-References

| Taxonomy | ID | Name / Label |
|----------|----|---------------|
| Cell Ontology (CL) | [CL:0000108](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000108) | cholinergic neuron |

Morphology & Electrophysiology

Morphology: cholinergic neuron (source: Cell Ontology)
Morphology can be inferred from Cell Ontology classification

PanglaoDB Marker Cross-References

Unknown (PanglaoDB):

External Database Links

[Cell Ontology (CL:0000108)](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000108)
[OBO Foundry (CL:0000108)](http://purl.obolibrary.org/obo/CL_0000108)
[Allen Brain Cell Atlas](https://portal.brain-map.org/atlases-and-data/bkp/abc-atlas)
[CellxGene Census](https://cellxgene.cziscience.com/)
[Human Cell Atlas](https://www.humancellatlas.org/)
[PanglaoDB](https://panglaodb.se/)

Taxonomy & Classification

| Database | ID | Name | Confidence |
|----------|----|------|------------|
| Cell Ontology | [CL:0000108](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000108) | cholinergic neuron | Medium |

PanglaoDB Marker Cross-References

Unknown (PanglaoDB):

External Database Links

[Cell Ontology (CL:0000108)](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000108)
[OBO Foundry (CL:0000108)](http://purl.obolibrary.org/obo/CL_0000108)
[Allen Brain Cell Atlas](https://portal.brain-map.org/atlases-and-data/bkp/abc-atlas)
[CellxGene Census](https://cellxgene.cziscience.com/)
[PanglaoDB](https://panglaodb.se/)

Morphology and Markers

Laterodorsal Tegmental (LDT) Cholinergic Neurons are identified by the expression of the following key marker genes:

CHAT
SLC5A7
SLC18A3
GABA
PENK

These markers are used for immunohistochemical identification and single-cell RNA sequencing classification, as catalogued in the [Allen Cell Type Atlas](https://portal.brain-map.org/atlases-and-data/rnaseq).

Normal Function

Laterodorsal Tegmental (LDT) Cholinergic Neurons play essential roles in neural circuits and brain function. They are found in the following brain regions:

Laterodorsal tegmental nucleus

Their normal functions include maintaining neural circuit integrity, signal processing, and contributing to the homeostasis of their local microenvironment.

Vulnerability in Disease

Laterodorsal Tegmental (LDT) Cholinergic Neurons show selective vulnerability in the following neurodegenerative conditions:

[Parkinson's Disease](/diseases/parkinsons-disease)
[Alzheimer's Disease](/diseases/alzheimers-disease)
Narcolepsy

The selective vulnerability of these cells is an active area of research, with factors including metabolic demands, calcium handling, exposure to toxic protein aggregates, and cell-autonomous gene expression programs contributing to their susceptibility.

Transcriptomic Profile

Single-cell and single-nucleus RNA sequencing studies have revealed the transcriptomic signature of Laterodorsal Tegmental (LDT) Cholinergic Neurons. Key differentially expressed genes from the Allen Cell Type Atlas and related datasets include the marker genes listed above. These transcriptomic profiles help identify subtypes and disease-associated gene expression changes.

Key Publications

[LDT cholinergic system in arousal and disease](https://doi.org/10.1038/s41583-021-00454-6). Nat Rev Neurosci, 2021.

External Links

Allen Cell Type Atlas: [https://portal.brain-map.org/atlases-and-data/rnaseq](https://portal.brain-map.org/atlases-and-data/rnaseq)
Allen Human Brain Atlas: [https://human.brain-map.org/](https://human.brain-map.org/)
[Cell Types Index](/cell-types)- [Diseases Index](/diseases)eases Index
[Mechanisms Index](/mechanisms) --

Background

The study of Laterodorsal Tegmental (Ldt) Cholinergic Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

📖 View canonical wiki page →