Presubiculum Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The presubiculum (also known as the postsubiculum) is a transitional cortical region between the subiculum and the parasubiculum within the hippocampal formation. It plays important roles in spatial navigation, head direction processing, and memory consolidation. [@aggleton2014]
Presubiculum Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The presubiculum (also known as the postsubiculum) is a transitional cortical region between the subiculum and the parasubiculum within the hippocampal formation. It plays important roles in spatial navigation, head direction processing, and memory consolidation. [@aggleton2014]
Gene therapy approaches for presubicular dysfunction
Key Publications
Van Strien NM, Cappaert NL, Witter MP (2009). The anatomy of memory: an interactive overview of the parahippocampal-hippocampal network. Nat Rev Neurosci. PMID: 20157559(https://pubmed.ncbi.nlm.nih.gov/20157559/)
Boccara CN, Sargolini F, Thuries VH, et al. (2010). Grid cells in pre- and parasubiculum. Nat Neurosci. PMID: 20010825(https://pubmed.ncbi.nlm.nih.gov/20010825/)
Sharp PE (1997). Subicular cells generate similar spatial firing patterns to place cells. Neuroscience. PMID: 9174135(https://pubmed.ncbi.nlm.nih.gov/9174135/)
Hargreaves EL, Rao G, Lee I, Knierim JJ (2005). Major dissociation between medial and lateral entorhinal input to dorsal hippocampus. Science. PMID: 15831751(https://pubmed.ncbi.nlm.nih.gov/15831751/)
Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K (2006). Staging of Alzheimer disease-type neurofibrillary tangles in the human brain. Acta Neuropathol. PMID: 16783324(https://pubmed.ncbi.nlm.nih.gov/16783324/)
Winter SS, Köhler S (2011). The integration of event signals in the presubiculum. [Hippocampus](/brain-regions/hippocampus). PMID: 21509754(https://pubmed.ncbi.nlm.nih.gov/21509754/)
Chen X, Gabbitas B, Taube JS (2016). The use of multivariate analysis to characterize the head direction cell system. J Neurophysiol. PMID: 26864768(https://pubmed.ncbi.nlm.nih.gov/26864768/)
Fyhn M, Hafting T, Witter MP, Moser MB, Moser EI (2007). Grid cells in mice. Hippocampus. PMID: 17663396(https://pubmed.ncbi.nlm.nih.gov/17663396/)
[Head Direction Cells - Scholarpedia](http://www.scholarpedia.org/article/Head_direction_cells)
Background
The study of Presubiculum Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.