Subiculum Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The subiculum is the primary output structure of the hippocampal formation, serving as the main gateway for hippocampal information to reach downstream targets including the entorhinal [cortex](/brain-regions/cortex), mammillary bodies, nucleus accumbens, prefrontal cortex, and amygdala. [@omara2014]
Subiculum Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The subiculum is the primary output structure of the hippocampal formation, serving as the main gateway for hippocampal information to reach downstream targets including the entorhinal [cortex](/brain-regions/cortex), mammillary bodies, nucleus accumbens, prefrontal cortex, and amygdala. [@omara2014]
Amaral DG, Lavenex P (2007). Hippocampal neuroanatomy. The [Hippocampus](/brain-regions/hippocampus) Book. Oxford University Press. PMID: 17462574(https://pubmed.ncbi.nlm.nih.gov/17462574/)
Pollard K, Shively J, Scherer S, et al. (2006). Prox1 gene expression in the human and rodent hippocampal formation. Brain Res. PMID: 16616139(https://pubmed.ncbi.nlm.nih.gov/16616139/)
Stewart M, Morris RG, Rushmer J (2005). The subiculum: gateway to hippocampal formation. Hippocampus. PMID: 15637677(https://pubmed.ncbi.nlm.nih.gov/15637677/)
Aggleton JP (2010). Multiple memory systems of the hippocampal formation. Nat Rev Neurosci. PMID: 20157559(https://pubmed.ncbi.nlm.nih.gov/20157559/)
Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K (2006). Staging of Alzheimer disease-type neurofibrillary tangles in the human brain. Acta Neuropathol. PMID: 16783324(https://pubmed.ncbi.nlm.nih.gov/16783324/)
Van Strien NM, Cappaert NL, Witter MP (2009). The anatomy of memory: an interactive overview of the parahippocampal-hippocampal network. Nat Rev Neurosci. PMID: 19139721(https://pubmed.ncbi.nlm.nih.gov/19139721/)
O'Mara SM, Commins S, Anderson M, Gigg J (2001). The subiculum: a review of form, physiology and function. Prog Neuropsychopharmacol Biol Psychiatry. PMID: 11301053(https://pubmed.ncbi.nlm.nih.gov/11301053/)
Floresco SB, Seamans JK, Phillips AG (1997). Selective roles for hippocampal, prefrontal cortical, and ventral striatal circuits in radial-arm maze tasks with or without a delay. J Neurosci. PMID: 9032808(https://pubmed.ncbi.nlm.nih.gov/9032808/)
[Subiculum Function - Scholarpedia](http://www.scholarpedia.org/article/Subiculum)
Background
The study of Subiculum Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Pathway Diagram
The following diagram shows the key molecular relationships involving Subiculum Neurons discovered through SciDEX knowledge graph analysis: