This index provides a comprehensive catalog of datasets relevant to neurodegenerative disease research, covering genomics, transcriptomics, proteomics, neuroimaging, and clinical data from major international consortia and research institutions. These datasets are essential resources for understanding disease mechanisms, identifying therapeutic targets, and developing biomarkers for Alzheimer's disease, Parkinson's disease, ALS, Huntington's disease, frontotemporal dementia, and other neurodegenerative conditions.
Neurodegenerative diseases affect millions of people worldwide, and understanding their underlying biology requires large-scale, high-quality datasets. The research community has generated numerous public datasets spanning multiple modalities including genomic datasets, transcriptomic datasets, proteomic datasets, neuroimaging datasets, clinical datasets, and neuropathology datasets[@beach2021].
The past decade has seen an unprecedented expansion in the availability of large-scale biomedical datasets, driven by decreasing sequencing costs, increased neuroimaging capacity, and coordinated international efforts to share data. This democratization of data has transformed neurodegenerative disease research, enabling unprecedented insights into disease mechanisms and accelerating therapeutic development[@weiner2012]. _Total: 26 pages_
Major Dataset Pages
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This index provides a comprehensive catalog of datasets relevant to neurodegenerative disease research, covering genomics, transcriptomics, proteomics, neuroimaging, and clinical data from major international consortia and research institutions. These datasets are essential resources for understanding disease mechanisms, identifying therapeutic targets, and developing biomarkers for Alzheimer's disease, Parkinson's disease, ALS, Huntington's disease, frontotemporal dementia, and other neurodegenerative conditions.
Neurodegenerative diseases affect millions of people worldwide, and understanding their underlying biology requires large-scale, high-quality datasets. The research community has generated numerous public datasets spanning multiple modalities including genomic datasets, transcriptomic datasets, proteomic datasets, neuroimaging datasets, clinical datasets, and neuropathology datasets[@beach2021].
The past decade has seen an unprecedented expansion in the availability of large-scale biomedical datasets, driven by decreasing sequencing costs, increased neuroimaging capacity, and coordinated international efforts to share data. This democratization of data has transformed neurodegenerative disease research, enabling unprecedented insights into disease mechanisms and accelerating therapeutic development[@weiner2012]. _Total: 26 pages_
Major Dataset Pages
Mermaid diagram (expand to render)
[Australian Imaging Biomarker Lifestyle Flagship Study of Ageing (AIBL)](/datasets/aibl)
| Dataset | Focus Area | Institution | Participants | Data Types | |---------|------------|--------------|--------------|------------| | ADNI | Alzheimer's disease neuroimaging | University of California | 1,000+ | MRI, PET, CSF, genetic | | PPMI | Parkinson's disease biomarkers | Michael J. Fox Foundation | 1,000+ | Clinical, imaging, biospecimens | | AMP-AD | Alzheimer's disease proteomics | Multiple | 2,000+ | RNA-seq, proteomics | | Allen Brain Atlas | Brain transcriptomics | Allen Institute | N/A | Transcriptomic | | UK Biobank | Population genetics | Wellcome Trust | 500,000 | Genetic, imaging, clinical | | PDBP | Parkinson's disease progression | National Institutes of Health | 2,000+ | Clinical, imaging | | Project MinE | ALS genetics | Multiple | 15,000 planned | Whole genome sequencing | | DIAN | Familial Alzheimer's | Washington University | 500+ | Longitudinal biomarker |
How to Access These Datasets
Most datasets require registration and acceptance of data use agreements. Key access portals include:
NIAGADS (National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site): Primary repository for ADNI and related Alzheimer's disease datasets
LONI IDA (Laboratory of Neuro Imaging Image and Data Archive): Neuroimaging data from ADNI and other studies
Synapse (AMP-AD and other NIH-funded data): Multi-omics data from the Accelerating Medicines Partnership
dbGaP (Database of Genotypes and Phenotypes): Genomic data from NIH-funded studies
GEO (Gene Expression Omnibus): Transcriptomic datasets from neurodegenerative disease studies
AWS Open Data: Cloud-based access to large datasets including UK Biobank
Related Sections
[Technologies](/technologies) — Technologies used in data acquisition](/technologies)
[Institutions](/institutions) — Institutions leading dataset collection](/institutions)
[Researchers](/researchers) — Researchers working with these datasets](/datasets)
[Alzheimer's Disease](/diseases/alzheimers-disease) — Diseases studied using these datasets](/datasets)
[Parkinson's Disease](/diseases/parkinsons-disease) — Related disease datasets](/datasets)
[ALS](/diseases/amyotrophic-lateral-sclerosis) — Motor neuron disease datasets