Disease Rankings

Disease Rankings

Overview

This page ranks neurodegenerative diseases by various criteria including research activity, clinical trial count, therapeutic development, and knowledge base coverage in NeuroWiki. [@geneprotein]

Rankings by Research Activity

| Rank | Disease | Research Activity | Clinical Trials |
|------|---------|-------------------|-----------------|
| 1 | Alzheimer's Disease | Very High | 200+ |
| 2 | Parkinson's Disease | Very High | 150+ |
| 3 | ALS | High | 100+ |
| 4 | Frontotemporal Dementia | High | 50+ |
| 5 | Huntington's Disease | Moderate-High | 40+ |
| 6 | Multiple System Atrophy | Moderate | 20+ |
| 7 | Progressive Supranuclear Palsy | Moderate | 15+ |
| 8 | Lewy Body Dementia | Moderate | 20+ |
| 9 | Corticobasal Degeneration | Low-Moderate | 10+ |
| 10 | Vascular Dementia | Moderate | 15+ |

Rankings by Knowledge Base Coverage

| Rank | Disease | Page Count | Content Depth |
|------|---------|------------|---------------|
| 1 | Alzheimer's Disease | 150+ | Comprehensive |
| 2 | Parkinson's Disease | 120+ | Comprehensive |
| 3 | ALS | 80+ | Detailed |
| 4 | Huntington's Disease | 60+ | Detailed |
| 5 | FTD | 50+ | Detailed |
| 6 | MSA | 30+ | Moderate |
| 7 | PSP | 25+ | Moderate |
| 8 | CBD | 20+ | Moderate |
| 9 | LBD | 15+ | Moderate |
| 10 | VaD | 10+ | Basic |

Rankings by Therapeutic Development

Disease Rankings

Overview

This page ranks neurodegenerative diseases by various criteria including research activity, clinical trial count, therapeutic development, and knowledge base coverage in NeuroWiki. [@geneprotein]

Rankings by Research Activity

| Rank | Disease | Research Activity | Clinical Trials |
|------|---------|-------------------|-----------------|
| 1 | Alzheimer's Disease | Very High | 200+ |
| 2 | Parkinson's Disease | Very High | 150+ |
| 3 | als | High | 100+ |
| 4 | Frontotemporal Dementia | High | 50+ |
| 5 | Huntington's Disease | Moderate-High | 40+ |
| 6 | Multiple System Atrophy | Moderate | 20+ |
| 7 | Progressive Supranuclear Palsy | Moderate | 15+ |
| 8 | Lewy Body Dementia | Moderate | 20+ |
| 9 | Corticobasal Degeneration | Low-Moderate | 10+ |
| 10 | Vascular Dementia | Moderate | 15+ |

Rankings by Knowledge Base Coverage

| Rank | Disease | Page Count | Content Depth |
|------|---------|------------|---------------|
| 1 | Alzheimer's Disease | 150+ | Comprehensive |
| 2 | Parkinson's Disease | 120+ | Comprehensive |
| 3 | ALS | 80+ | Detailed |
| 4 | Huntington's Disease | 60+ | Detailed |
| 5 | FTD | 50+ | Detailed |
| 6 | MSA | 30+ | Moderate |
| 7 | PSP | 25+ | Moderate |
| 8 | CBD | 20+ | Moderate |
| 9 | LBD | 15+ | Moderate |
| 10 | VaD | 10+ | Basic |

Rankings by Therapeutic Development

| Rank | Disease | Approved Treatments | Pipeline Candidates |
|------|---------|-------------------|---------------------|
| 1 | Alzheimer's Disease | 7 | 100+ |
| 2 | Parkinson's Disease | 20+ | 80+ |
| 3 | ALS | 3 | 60+ |
| 4 | Huntington's Disease | 1 | 40+ |
| 5 | FTD | 0 | 30+ |
| 6 | MSA | 0 | 15+ |
| 7 | PSP | 0 | 12+ |
| 8 | CBD | 0 | 10+ |
| 9 | LBD | 3 | 10+ |
| 10 | VaD | 2 | 8+ |

Disease Categories

Tauopathies

Diseases characterized by [tau protein](/proteins/tau) pathology:

• [Alzheimer's Disease](/diseases/alzheimers-disease) — Most common cause of dementia
• [Progressive Supranuclear Palsy](/diseases/progressive-supranuclear-palsy) — Tauopathy with vertical gaze palsy
• [Corticobasal Degeneration](/diseases/corticobasal-degeneration) — Asymmetric cortical and basal ganglia syndrome
• [Primary Age-Related Tauopathy](/diseases/primary-age-related-tauopathy) — Aging-associated tau pathology

Synucleinopathies

Diseases characterized by [alpha-synuclein](/proteins/alpha-synuclein) pathology:

• [Parkinson's Disease](/diseases/parkinsons-disease) — Movement disorder with Lewy bodies
• [Lewy Body Dementia](/diseases/lewy-body-dementia) — Fluctuating cognition and visual hallucinations
• [Multiple System Atrophy](/diseases/multiple-system-atrophy) — Autonomic failure with parkinsonism

TDP-43 Proteinopathies

Diseases characterized by [TDP-43](/mechanisms/tdp-43-proteinopathy) pathology:

• [ALS](/diseases/amyotrophic-lateral-sclerosis) — Motor neuron disease
• [Frontotemporal Dementia](/diseases/frontotemporal-dementia) — Behavioral and language variants

Other Neurodegenerative Diseases

• [Huntington's Disease](/diseases/huntingtons) — CAG repeat expansion disorder
• [Vascular Dementia](/diseases/vascular-dementia) — Cognitive decline from cerebrovascular disease

Research Trends

Alzheimer's Disease dominates research activity with over 200 active clinical trials and the largest therapeutic pipeline. The approval of [lecanemab](/entities/lecanemab) and [donanemab](/entities/donanemab) represents a milestone in disease-modifying therapy development.

Parkinson's Disease has the highest number of approved treatments (20+) but remains without disease-modifying therapies. Focus is on alpha-synuclein targeting and neuroprotection.

ALS has seen recent momentum with FDA approvals (AMX0035, tofersen) but remains critically undertreated. Genetic understanding ([C9orf72](/entities/c9orf72), SOD1, FUS) is driving targeted therapy development.

Coverage Gaps

Top Entries with Thin Coverage

These ranked items have limited content and would benefit from expansion:

• [Primary Age-Related Tauopathy](/diseases/primary-age-related-tauopathy) — 9,562 characters
• [Progressive Supranuclear Palsy](/diseases/progressive-supranuclear-palsy) — 10,335 characters
• [ALS](/diseases/amyotrophic-lateral-sclerosis) — 13,173 characters
• [Lewy Body Dementia](/diseases/lewy-body-dementia) — 13,522 characters

External Links

• [PubMed](https://pubmed.ncbi.nlm.nih.gov/)
• [KEGG Pathways](https://www.genome.jp/kegg/pathway.html)

References

See Also

• [ACVR1 Gene](/wiki/genes-acvr1) — interacts_with
• [Riluzole ALS Trials](/wiki/clinical-trials-riluzole-als) — interacts_with
• [CBL Gene](/wiki/genes-cbl) — associated_with
• [CDC42 Gene](/wiki/genes-cdc42) — interacts_with