Entities

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index822 wordssynced 2026-04-02

Overview

This index provides a clean navigation layer for the `entities` section of NeuroWiki. It currently lists 185 published entities pages and is regenerated from live Wiki.js metadata to avoid recursive markdown-link corruption.

_Total: 185 pages_

All Pages

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Overview

_Total: 185 pages_

All Pages

[ABCA7 (ATP-Binding Cassette Transporter A7)](/entities/abca7)
[AC-193](/entities/ac-193)
[Acetylcholine](/entities/acetylcholine)
[Adenosine A2A Receptor](/entities/adenosine-a2a-receptor)
[Aduhelm](/entities/aduhelm)
[AL001](/entities/al001)
[AMPK (AMP-Activated Protein Kinase)](/entities/ampk)
[Amyloid PET Imaging](/entities/amyloid-pet)
[Amyloid Precursor Protein (APP)](/entities/app-protein)
[Amyloid-Related Imaging Abnormalities (ARIA)](/entities/aria-imaging)
[Apoptosis in Neurodegeneration](/entities/apoptosis)
[Astrocytes](/entities/astrocytes)
[ATP7B Gene](/entities/atp7b-gene)
[Atrophin-1 Protein](/entities/atrophin-1)
[Autonomic Nervous System](/entities/autonomic-nervous-system)
[Autophagy](/entities/autophagy)
[BACE1 (Beta-Secretase)](/entities/bace1)
[BIIB080 (MAPTRx)](/entities/biiib080)
[BIIB122](/entities/biiib122)
[Blarcamesine](/entities/blarcamesine)
[Blood-Brain Barrier](/entities/blood-brain-barrier)
[BNIP1 Protein (BCL2-Interacting Protein 1)](/entities/bnip1-protein)
[Brain Insulin Signaling](/entities/brain-insulin-signaling)
[BSE (Bovine Spongiform Encephalopathy)](/entities/bse)
[Buntanetap](/entities/buntanetap)
[Brain Health Roundtable and AADAPT Act](/entities/brain-health-roundtable-aadapt-act)
[C9orf72 (Chromosome 9 Open Reading Frame 72)](/entities/c9orf72)
[C9orf72 Protein (Chromosome 9 Open Reading Frame 72)](/entities/c9orf72-protein)
[Calpains](/entities/calpains)
[Caspases](/entities/caspases)
[Cholinesterase Inhibitors](/entities/cholinesterase-inhibitors)
[CNTFR Gene](/entities/cntfr-gene)
[Complement System](/entities/complement-system)
[Crenezumab](/entities/crenezumab)
[DIAN-Observational Study (DIAN-O)](/entities/dian-observational-study)
[DJ-1 (PARK7)](/entities/dj1)
[DNA Methylation](/entities/dna-methylation)
[DNL151](/entities/dnl151)
[DNL310](/entities/dnl310)
[Dominantly Inherited Alzheimer Network (DIAN)](/entities/dian-study)
[Donanemab (Kisunla)](/entities/donanemab)
[Donepezil](/entities/donepezil)
[Dopamine](/entities/dopamine)
[Dopaminergic Neurons](/entities/dopaminergic-neurons)
[Entities Overview](/entities/overview)
[Entities Quality Rankings](/entities/quality-rankings)
[Excitotoxicity](/entities/excitotoxicity)
[Exosomes](/entities/exosomes)
[Expand Hsp90 content](/entities/hsp90-protein)
[Expand Microtubules content](/entities/microtubules)
[FDG PET Imaging](/entities/fdg-pet)
[Ferroptosis](/entities/ferroptosis)
[Fosramatine](/entities/fosramatine)
[FPN1 (Ferroportin)](/entities/fpn1)
[FUS (Fused in Sarcoma)](/entities/fus)
[FUS Protein (Fused in Sarcoma)](/entities/fus-protein)
[Gamma-Aminobutyric Acid (GABA)](/entities/gaba)
[Gamma-Secretase Complex](/entities/gamma-secretase)
[Gantenerumab](/entities/gantenerumab)
[GBA Gene](/entities/gba)
[GBA1 (Glucocerebrosidase)](/entities/gba1)
[Glial Cell Line-Derived Neurotrophic Factor (GDNF)](/entities/gdnf)
[Glial Fibrillary Acidic Protein (GFAP)](/entities/gfap)
[Glial Fibrillary Acidic Protein (GFAP)](/entities/glial-fibrillary-acidic-protein)
[GLP-1 Receptor (Glucagon-Like Peptide-1 Receptor)](/entities/glp1-receptor)
[Glutamate](/entities/glutamate)
[Glymphatic System](/entities/glymphatic-system)
[GRM1 Gene](/entities/grm1-gene)
[GRM5 Gene](/entities/grm5-gene)
[GRM7 Gene](/entities/grm7-gene)
[GRN (Progranulin)](/entities/grn)
[GSK-3β](/entities/gsk3-beta)
[GT-02287](/entities/gt-02287)
[Gut-Brain Axis](/entities/gut-brain-axis)
[HDAC6 (Histone Deacetylase 6)](/entities/hdac6)
[Heat Shock Proteins](/entities/heat-shock-proteins)
[Hepcidin (HAMP)](/entities/hepcidin)
[HEXA (Hexosaminidase A)](/entities/hexa)
[Histamine](/entities/histamine)
[Histone Deacetylase (HDAC) Enzymes](/entities/hdac-enzymes)
[Histone Deacetylases (HDACs)](/entities/histone-deacetylase)
[Histone Methylation](/entities/histone-methylation)
[Histone Modifications](/entities/histone-modifications)
[IL6 Gene](/entities/il6)
[Insulin Receptor Substrate 1 (IRS-1)](/entities/irs-1)
[Interleukin-6 (IL-6)](/entities/interleukin-6)
[IRS-1 (Insulin Receptor Substrate 1)](/entities/irs1)
[LAF1 Protein (La-Related Protein 1)](/entities/laf1-protein)
[Lecanemab (Leqembi)](/entities/lecanemab)
[Long-Term Potentiation (LTP)](/entities/ltp)
[LRRK2 (Leucine-Rich Repeat Kinase 2)](/entities/lrrk2)
[LRRK2 Protein (Leucine-Rich Repeat Kinase 2)](/entities/lrrk2-protein)
[Microbiome](/entities/microbiome)
[Microglia](/entities/microglia)
[Microglia in Neurodegeneration](/entities/microglia-in-neurodegeneration)
[Mitochondria](/entities/mitochondria)
[Mitochondrial Dynamics](/entities/mitochondrial-dynamics)
[MOSPD1 Protein (Motile Sperm Domain-Containing Protein 1)](/entities/mospd1-protein)
[MSH3 (MutS Homolog 3)](/entities/msh3)
[MTHFR (Methylenetetrahydrofolate Reductase)](/entities/mthfr)
[mTOR (Mechanistic Target of Rapamycin)](/entities/mtor)
[Necroptosis](/entities/necroptosis)
[Neprilysin (NEP)](/entities/neprilysin)
[Neurogenesis](/entities/neurogenesis)
[Neurons](/entities/neurons)
[NF-κB (Nuclear Factor Kappa B)](/entities/nf-kb)
[NGF Gene](/entities/ngf)
[NLRP3 Inflammasome](/entities/nlrp3-inflammasome)
[NMDA Receptor](/entities/nmda-receptor)
[Norepinephrine (Noradrenaline)](/entities/norepinephrine)
[NTRK1 Gene](/entities/ntrk1)
[Nucleus Basalis of Meynert](/entities/nucleus-basalis-meynert)
[Oligodendrocytes](/entities/oligodendrocytes)
[p62/SQSTM1 (Sequestosome-1)](/entities/p62-sqstm1)
[Parkin (PARK2)](/entities/parkin-protein)
[PBKR03](/entities/pbkr03)
[PC12 Cell Line](/entities/pc12-cell-line)
[PINK1 (PTEN-Induced Kinase 1)](/entities/pink1-protein)
[PLD4 (Phospholipase D Family Member 4)](/entities/pld4)
[PNT001](/entities/pnt001)
[PP2A](/entities/pp2a)
[PPAR (Peroxisome Proliferator-Activated Receptor)](/entities/ppar)
[PR001](/entities/pr001)
[Prasinezumab](/entities/prasinezumab)
[Presenilin 1 (PSEN1)](/entities/psen1)
[Presenilin 2 (PSEN2)](/entities/psen2)
[Presenilin-1 (PS1)](/entities/presenilin-1)
[Prion-Like Spreading](/entities/prion-like-spreading)
[PRNP (Prion Protein Gene)](/entities/prnp-gene)
[PRNP Gene](/entities/prnp)
[PRX005](/entities/prx005)
[PRX012](/entities/prx012)
[PSD-95 (Postsynaptic Density Protein 95)](/entities/psd-95)
[Reactive Oxygen Species (ROS)](/entities/reactive-oxygen-species)
[Reactive Oxygen Species (ROS)](/entities/ros)
[Remternetug](/entities/remternetug)
[Rivastigmine](/entities/rivastigmine)
[Ryanodine Receptor](/entities/ryanodine-receptor)
[SEL1L](/entities/sel1l)
[Semorinemab](/entities/semorinemab)
[Serotonin (5-Hydroxytryptamine, 5-HT)](/entities/serotonin)
[Simufilam](/entities/simufilam)
[SIRT1 (Sirtuin 1)](/entities/sirt1)
[SNX5 (Sorting Nexin 5)](/entities/snx5)
[SOD1 (Superoxide Dismutase 1)](/entities/sod1)
[SOD1 Protein (Superoxide Dismutase 1)](/entities/sod1-protein)
[SH-SY5Y Cell Line](/entities/sh-sy5y)
[SORL1 (Sortilin-Related Receptor 1)](/entities/sorl1)
[SPG7 — Spastic Paraplegia 7](/entities/spg7)
[SQSTM1/p62](/entities/sqstm1-p62)
[STAT3 (Signal Transducer and Activator of Transcription 3)](/entities/stat3)
[Tau Oligomers](/entities/tau-oligomers)
[Tau PET Imaging in Neurodegenerative Disease](/entities/tau-pet)
[TFEB (Transcription Factor EB)](/entities/tfeb)
[TLR4 (Toll-Like Receptor 4)](/entities/tlr4)
[TNF Gene](/entities/tnf)
[TREM2 Protein (Triggering Receptor Expressed on Myeloid Cells 2)](/entities/trem2-protein)
[TrkB Signaling](/entities/trkb-signaling)
[Tumor Necrosis Factor (TNF)](/entities/tumor-necrosis-factor)
[UB-312](/entities/ub-312)
[UBQLN2 Protein (Ubiquilin-2)](/entities/ubqln2-protein)
[Unfolded Protein Response](/entities/unfolded-protein-response)
[Unfolded Protein Response (UPR)](/entities/upr)
[VIRMA (KIAA1429)](/entities/virma-kiaa1429)
[XPro1595](/entities/xpro1595)
[α-Tubulin (Alpha-Tubulin)](/entities/alpha-tubulin)

Additional Entity Pages

[RNF128 (Graf1/XTP3) Gene](/entities/rnf128)

Coverage Gaps

Missing Entity Categories

Metabolic Entities: Limited coverage of metabolic pathway components (e.g., glycolysis enzymes, TCA cycle components)
Epigenetic Entities: Missing many histone modifiers, chromatin regulators beyond existing coverage
Ion Channel Entities: Few voltage-gated calcium/potassium channel entities indexed
Neurotrophic Factor Entities: Limited coverage of GDNF family ligands and receptors beyond existing

Organization Issues

Mixed content: proteins, drugs, pathways, concepts all in same section
Could benefit from sub-indexes (protein entities, drug entities, pathway entities)
Many gene aliases not cross-linked

Could benefit from drug pipeline sub-index
Need better pathway-component cross-linking to mechanisms section

[Proteins](/proteins) — Protein components of molecular entities
[Genes](/genes) — Gene products forming entities
[Mechanisms](/mechanisms) — Pathways involving these entities
[Therapeutics](/therapeutics) — Targeting these entities

References

Unknown, Wiki.js GraphQL API Documentation (n.d.)

Pathway Diagram

The following diagram shows the key molecular relationships involving Entities discovered through SciDEX knowledge graph analysis:

Mermaid diagram (expand to render)

From the [SciDEX Exchange](/exchange) — scored by multi-agent debate

[Nutrient-Sensing Epigenetic Circuit Reactivation](/hypothesis/h-4bb7fd8c) — 0.79 · Target: SIRT1
[Selective Acid Sphingomyelinase Modulation Therapy](/hypothesis/h-de0d4364) — 0.77 · Target: SMPD1
[TREM2-Dependent Microglial Senescence Transition](/hypothesis/h-61196ade) — 0.76 · Target: TREM2
[APOE-Dependent Autophagy Restoration](/hypothesis/h-51e7234f) — 0.73 · Target: MTOR
[Cell-Type Specific TREM2 Upregulation in DAM Microglia](/hypothesis/h-seaad-51323624) — 0.70 · Target: TREM2
[Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflammatory Priming](/hypothesis/h-f3fb3b91) — 0.67 · Target: TLR4
[APOE-TREM2 Interaction Modulation](/hypothesis/h-180807e5) — 0.66 · Target: TREM2
[Astrocyte-Mediated Neuronal Epigenetic Rescue](/hypothesis/h-8fe389e8) — 0.64 · Target: HDAC

Related Analyses:

[Lipid raft composition changes in synaptic neurodegeneration](/analysis/SDA-2026-04-01-gap-lipid-rafts-2026-04-01) 🔄

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Entities

Overview

All Pages

Overview

All Pages

Additional Entity Pages

Coverage Gaps

Missing Entity Categories

Organization Issues

Related Index Needs

Related Sections

See Also

References

Pathway Diagram

Related Hypotheses