Aldh1A1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Aldh1A1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-gene"> [@jacobs2013]
<div class="infobox-header">ALDH1A1</div> [@galter2010]
<div class="infobox-row"><span class="infobox-label">Gene Symbol</span><span class="infobox-value">ALDH1A1</span></div> [@maeda2011]
<div class="infobox-row"><span class="infobox-label">Full Name</span><span class="infobox-value">Aldehyde Dehydrogenase 1 Family Member A1</span></div> [@edenberg2014]
<div class="infobox-row"><span class="infobox-label">Chromosomal Location</span><span class="infobox-value">9q21.33</span></div>
<div class="infobox-row"><span class="infobox-label">NCBI Gene ID</span><span class="infobox-value"><a href="https://www.ncbi.nlm.nih.gov/gene/216" target="_blank">216</a></span></div>
<div class="infobox-row"><span class="infobox-label">OMIM</span><span class="infobox-value"><a href="https://www.omim.org/entry/171255" target="_blank">171255</a></span></div>
<div class="infobox-row"><span class="infobox-label">Ensembl ID</span><span class="infobox-value"><a href="https://ensembl.org/Homo_sapiens/ENSG00000153208" target="_blank">ENSG00000153208</a></span></div>
<div class="infobox-row"><span class="infobox-label">UniProt ID</span><span class="infobox-value"><a href="https://www.uniprot.org/uniprot/P00342" target="_blank">P00342</a></span></div>
<div class="infobox-row"><span class="infobox-label">Associated Diseases</span><span class="infobox-value">[Parkinson's Disease](/diseases/parkinsons-disease), Sjögren-Larsson Syndrome, Alcohol Sensitivity</span></div>
</div>
ALDH1A1 Gene is involved in biological pathways relevant to neurodegenerative diseases. It plays important roles in neuronal function, cellular signaling, ion transport, protein homeostasis, or stress response mechanisms.
Dysregulation or mutations in this gene contribute to the pathogenesis of [Alzheimer's disease](/diseases/alzheimers-disease), [Parkinson's disease](/diseases/parkinsons-disease), and related neurodegenerative disorders.
ALDH1A1 encodes aldehyde dehydrogenase 1A1, a cytosolic enzyme that catalyzes the oxidation of aldehydes to carboxylic acids. It plays critical roles in detoxification of lipid peroxidation products (such as 4-hydroxynonenal), retinol metabolism, and conversion of retinol to retinoic acid.[@wey2012]
In the brain, ALDH1A1 is particularly important in dopaminergic [neurons](/entities/neurons) where it protects against aldehyde toxicity generated during dopamine metabolism. The enzyme also produces retinoic acid, which is essential for neuronal development and plasticity.[@jacobs2013]
ALDH1A1 is expressed in multiple brain regions:
The study of Aldh1A1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
The following diagram shows the key molecular relationships involving ALDH1A1 Gene discovered through SciDEX knowledge graph analysis: