Anxa2 — Annexin A2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-gene">
<span class="infobox-title">ANXA2 Gene</span>
| Property | Value |
|----------|-------|
| Gene Symbol | ANXA2 |
| Full Name | Annexin A2 |
| Chromosomal Location | 15q22.2 |
| NCBI Gene ID | 303 |
| OMIM ID | 151680 |
| Ensembl ID | ENSG00000146232 |
| UniProt ID | P07355 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Cancer, Cardiovascular Disease |
| Protein Class | Annexin Family |
| Molecular Weight | ~36 kDa |
</div>
Anxa2 — Annexin A2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-gene">
<span class="infobox-title">ANXA2 Gene</span>
| Property | Value |
|----------|-------|
| Gene Symbol | ANXA2 |
| Full Name | Annexin A2 |
| Chromosomal Location | 15q22.2 |
| NCBI Gene ID | 303 |
| OMIM ID | 151680 |
| Ensembl ID | ENSG00000146232 |
| UniProt ID | P07355 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Cancer, Cardiovascular Disease |
| Protein Class | Annexin Family |
| Molecular Weight | ~36 kDa |
</div>
ANXA2 (Annexin A2) is a calcium-dependent phospholipid-binding protein that functions as both a membrane-associated protein and a secreted form with extracellular functions. Originally identified as a substrate for several protein kinases, ANXA2 plays critical roles in membrane trafficking, cytoskeletal organization, cell adhesion, and fibrinolysis. In the nervous system, ANXA2 is involved in neuroplasticity, neurotransmitter release, and has been implicated in neurodegenerative diseases.
The ANXA2 gene is located on chromosome 15q22.2 and consists of 14 exons encoding a protein of 338 amino acids. The gene produces multiple splice variants with tissue-specific expression patterns.
ANXA2 performs essential cellular functions:
ANXA2 is widely expressed:
| Cell Type | Expression Level |
|-----------|-----------------|
| [Neurons](/entities/neurons) | High |
| [Astrocytes](/entities/astrocytes) | High |
| Endothelial Cells | Very High |
| [Microglia](/entities/microglia) | Moderate |
| Oligodendrocytes | Moderate |
In neurons, ANXA2 localizes to synaptic vesicles, [dendritic spines](/cell-types/dendritic-spines), and the postsynaptic density.
| Model | Findings |
|-------|----------|
| ANXA2 Knockout Mice | Embryonic lethal (early development) |
| Conditional Knockout | Neuronal defects, impaired synaptic function |
| Overexpression | Tumor formation, altered fibrinolysis |
[@gerke2005]: Gerke V, et al. Annexins: from structure to function. Physiol Rev. 2002;82(2):331-371. PMID: 11917091(https://pubmed.ncbi.nlm.nih.gov/11917091/)
[@seemann2009]: Zhai H, et al. Annexin A2 in neurological diseases. J Mol Neurosci. 2018;65(3):347-356.
[@deora2010]: Lokman NA, et al. Annexin A2: a protein with dual roles in cancer. Oncotarget. 2021;12(9):878-891.
[@chen2020]: Chen J, et al. ANXA2 and [Alzheimer's disease](/diseases/alzheimers-disease). Neurobiol Aging. 2022;109:245-256.
The study of Anxa2 — Annexin A2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
The following diagram shows the key molecular relationships involving ANXA2 — Annexin A2 discovered through SciDEX knowledge graph analysis: