CBX7 — Chromobox 7 is a component of the Polycomb Repressive Complex 1 (PRC1), a key epigenetic regulator that maintains gene silencing through histone modification. CBX7 specifically recognizes H3K27me3 marks deposited by PRC2 and contributes to transcriptional repression of developmental genes. Dysregulation of CBX7 has been implicated in cancer and neurodegenerative diseases. [@vandermeulen2020]
Introduction
CBX7 encodes chromobox protein homolog 7, a member of the Polycomb group (PcG) family of epigenetic repressors. As part of PRC1, CBX7 binds to trimethylated lysine 27 on histone H3 (H3K27me3) through its chromodomain, and uses its repressive box (RC) domain to compact chromatin and maintain gene silencing. CBX7 is essential for maintaining cellular identity and preventing aberrant activation of developmental genes. [@simon2022]
<div class="infobox infobox-gene">
| Property | Value | |----------|-------| | Gene Symbol | CBX7 | | Full Name | Chromobox 7 | | Chromosomal Location | 22q13.1 | | NCBI Gene ID | 23492 | | OMIM ID | 607860 | | Ensembl ID | ENSG00000105976 | | UniProt ID | O95931 | | Encoded Protein | Chromobox protein homolog 7 (CBX7) | | Associated Diseases | Alzheimer's disease, Parkinson's disease, cancer, intellectual disability |
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Function
CBX7 encodes a PRC1 component with the following normal functions:
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title: CBX7 Gene
CBX7 (Chromobox 7)
Overview
CBX7 — Chromobox 7 is a component of the Polycomb Repressive Complex 1 (PRC1), a key epigenetic regulator that maintains gene silencing through histone modification. CBX7 specifically recognizes H3K27me3 marks deposited by PRC2 and contributes to transcriptional repression of developmental genes. Dysregulation of CBX7 has been implicated in cancer and neurodegenerative diseases. [@vandermeulen2020]
Introduction
CBX7 encodes chromobox protein homolog 7, a member of the Polycomb group (PcG) family of epigenetic repressors. As part of PRC1, CBX7 binds to trimethylated lysine 27 on histone H3 (H3K27me3) through its chromodomain, and uses its repressive box (RC) domain to compact chromatin and maintain gene silencing. CBX7 is essential for maintaining cellular identity and preventing aberrant activation of developmental genes. [@simon2022]
<div class="infobox infobox-gene">
| Property | Value | |----------|-------| | Gene Symbol | CBX7 | | Full Name | Chromobox 7 | | Chromosomal Location | 22q13.1 | | NCBI Gene ID | 23492 | | OMIM ID | 607860 | | Ensembl ID | ENSG00000105976 | | UniProt ID | O95931 | | Encoded Protein | Chromobox protein homolog 7 (CBX7) | | Associated Diseases | Alzheimer's disease, Parkinson's disease, cancer, intellectual disability |
</div>
Function
CBX7 encodes a PRC1 component with the following normal functions:
Transcriptional repression - Maintains silencing of developmental genes
Histone recognition - Binds H3K27me3 through chromodomain