Ccr5 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Overview
CCR5 Gene is involved in neurodegenerative diseases. This page provides comprehensive information about its function, disease associations, expression patterns, molecular mechanisms, and therapeutic implications. [@ccra]
Ccr5 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Overview
CCR5 Gene is involved in neurodegenerative diseases. This page provides comprehensive information about its function, disease associations, expression patterns, molecular mechanisms, and therapeutic implications. [@ccra]
[@ccrb] '''CCR5''' (C-C Motif Chemokine Receptor 5) is a G protein-coupled receptor that plays crucial roles in neuroinflammation and immune cell trafficking. It is best known as a co-receptor for HIV entry but also has important functions in neurodegenerative diseases. [@ccrc]
Function
CCR5 is a seven-transmembrane G protein-coupled receptor that binds CCL3 (MIP-1α), CCL4 (MIP-1β), and CCL5 (RANTES). It is expressed on various immune cells and, to a lesser extent, on neurons and glial cells. [@ccrd]
Key functions include:
Immune cell recruitment: Chemoattraction of monocytes, T cells, [microglia](/cell-types/microglia-neuroinflammation)
Neuroinflammation modulation: Mediates inflammatory responses in CNS
HIV co-receptor: Primary co-receptor for R5-tropic HIV-1
Neuroprotection: Some evidence for neuroprotective effects
Pain modulation: Involved in neuropathic pain signaling
Disease Associations
Alzheimer's Disease
CCR5 expression elevated in AD brain
May contribute to chronic neuroinflammation
Genetic variants affect AD risk
Therapeutic targeting under investigation
Parkinson's Disease
Increased CCR5 in substantia nigra
Associated with microglial activation
May influence dopaminergic neuron survival
CCR5 antagonists explored
HIV-Associated Neurocognitive Disorders
Primary co-receptor for HIV-1 entry
HIV-associated neuroinflammation
Maraviroc (CCR5 antagonist) effects on cognition
Multiple Sclerosis
CCR5+ T cells in MS lesions
Contributes to autoimmune inflammation
CCR5 antagonists in clinical trials
Stroke
Upregulated following ischemic injury
Mediates inflammatory damage
Target for neuroprotection
Expression
CCR5 expression in the brain:
[Microglia](/entities/microglia): Low basal, upregulated with activation
[Aβ](/proteins/amyloid-beta) interaction: CCR5 involvement in amyloid pathology
Neuroinflammation: Enhanced CCL5 in AD brain
Cognitive decline: Correlations with disease severity
Genetic variants: CCR5-Δ32 and AD risk
Parkinson's Disease
Dopaminergic vulnerability: CCR5 expression on neurons
Neuroinflammation: Microglial CCL5 production
Therapeutic potential: CCR5 modulation
Multiple Sclerosis
Lesion formation: T cell recruitment via CCL5
[Blood-brain barrier](/entities/blood-brain-barrier): Transmigration of immune cells
Clinical trials: CCR5 antagonists
Background
The study of Ccr5 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Allen Brain Atlas Resources
The Allen Brain Atlas provides comprehensive gene expression data across brain regions and cell types.
[Allen Human Brain Atlas](https://human.brain-map.org/) — Gene expression data across the adult human brain
[Allen Mouse Brain Atlas](https://mouse.brain-map.org/) — Gene expression in mouse brain
[Allen Cell Type Atlas](https://celltypes.brain-map.org/) — Single-cell transcriptomics data
[Allen Brain Map Portal](https://portal.brain-map.org/) — Access to all Allen Institute brain data
Search for expression data on the Allen Brain Atlas:
[Human Brain Atlas search for CCR5](https://human.brain-map.org/microarray/search/show?search_term=CCR5)
[Mouse Brain Atlas search for Ccr5](https://mouse.brain-map.org/search/index.html?query=Ccr5)
References
[Unknown, - CCR5 as HIV co-receptor (n.d.)](https://pubmed.ncbi.nlm.nih.gov/9177280/)
[Unknown, - CCR5 in CNS (n.d.)](https://pubmed.ncbi.nlm.nih.gov/10430154/)
[Unknown, - CCR5 in neuroinflammation (n.d.)](https://pubmed.ncbi.nlm.nih.gov/14645077/)
[Unknown, - CCR5 in AD (n.d.)](https://pubmed.ncbi.nlm.nih.gov/19056645/)
[Unknown, - CCR5 antagonists in neurological disease (n.d.)](https://pubmed.ncbi.nlm.nih.gov/25526673/)
Pathway Context
Mermaid diagram (expand to render)
Pathway Diagram
The following diagram shows the key molecular relationships involving CCR5 Gene discovered through SciDEX knowledge graph analysis: