| Property | Value | |---------|-------| | Gene Symbol | CDK11A | | Full Name | Cyclin Dependent Kinase 11A | | Chromosome | 1p36.21 | | NCBI Gene ID | [984](https://www.ncbi.nlm.nih.gov/gene/984) | | Ensembl ID | ENSG00000089234 | | UniProt ID | [Q9UQ88](https://www.uniprot.org/uniprot/Q9UQ88) | | OMIM | 176871 | | Protein Length | 795 amino acids | | Primary Function | RNA splicing, cell cycle regulation, transcription | | Expression | Ubiquitous, high in brain | | Associated Diseases | Cancer, AD, PD, ALS | </aside>
CDK11A — Cyclin Dependent Kinase 11A
Overview
CDK11A (Cyclin-Dependent Kinase 11A) is a member of the cyclin-dependent kinase (CDK) family that plays critical roles in RNA splicing, cell cycle regulation, and transcription. Located on chromosome 1p36.21, this gene encodes a serine/threonine protein kinase that is ubiquitously expressed with particularly high levels in the brain[@cdk11a_overview][@cdk11a_uniprot].
CDK11A is unique among CDKs in that it is encoded by a gene that also produces CDK11B through alternative splicing. Together, these isoforms form the CDK11 family, which is involved in numerous cellular processes relevant to neuronal function and neurodegeneration. The kinase has emerged as a potential therapeutic target in neurodegenerative diseases due to its roles in RNA processing, stress responses, and neuronal survival[@cdk11a_therapy2023].
| Property | Value | |---------|-------| | Gene Symbol | CDK11A | | Full Name | Cyclin Dependent Kinase 11A | | Chromosome | 1p36.21 | | NCBI Gene ID | [984](https://www.ncbi.nlm.nih.gov/gene/984) | | Ensembl ID | ENSG00000089234 | | UniProt ID | [Q9UQ88](https://www.uniprot.org/uniprot/Q9UQ88) | | OMIM | 176871 | | Protein Length | 795 amino acids | | Primary Function | RNA splicing, cell cycle regulation, transcription | | Expression | Ubiquitous, high in brain | | Associated Diseases | Cancer, AD, PD, ALS | </aside>
CDK11A — Cyclin Dependent Kinase 11A
Overview
CDK11A (Cyclin-Dependent Kinase 11A) is a member of the cyclin-dependent kinase (CDK) family that plays critical roles in RNA splicing, cell cycle regulation, and transcription. Located on chromosome 1p36.21, this gene encodes a serine/threonine protein kinase that is ubiquitously expressed with particularly high levels in the brain[@cdk11a_overview][@cdk11a_uniprot].
CDK11A is unique among CDKs in that it is encoded by a gene that also produces CDK11B through alternative splicing. Together, these isoforms form the CDK11 family, which is involved in numerous cellular processes relevant to neuronal function and neurodegeneration. The kinase has emerged as a potential therapeutic target in neurodegenerative diseases due to its roles in RNA processing, stress responses, and neuronal survival[@cdk11a_therapy2023].
Gene Structure and Protein Architecture
Gene Organization
The CDK11A gene spans approximately 12 kb and consists of 18 exons encoding a 795-amino acid protein with a molecular weight of approximately 92 kDa. The gene is evolutionarily conserved across vertebrates.
Protein Domains
Mermaid diagram (expand to render)
N-terminal Region: Contains serine-rich sequences and cyclin interaction motifs
Kinase Domain (aa 150-350): Catalytic domain with typical CDK active site motifs
C-terminal Region: Regulatory sequences including nuclear localization signals
Isoforms
CDK11A produces multiple isoforms:
CDK11A^p110: Full-length 110 kDa isoform
CDK11A^p58: Smaller isoform generated through internal translation initiation
Molecular Functions
RNA Splicing
CDK11A is a key regulator of RNA splicing:
Spliceosome Assembly: Phosphorylates components of the spliceosome
Alternative Splicing: Regulates differential splicing of pre-mRNA
Splicing Factors: Modulates activity of SR proteins and hnRNPs