Clusterin is a Chaperone protein involved in lipid transport, protein folding, and neurodegeneration. Associated with [Alzheimer's disease](/diseases/alzheimers-disease) and other age-related diseases.
title: CLU Gene [@bhattacharjee2011]
--- [@last2020]
CLU (Clusterin)
Introduction
Clu Gene Clusterin is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@sato2019]
| Property | Value | [@nonis2022] |----------|-------| [@kumar2021] | Gene Symbol | CLU | | Full Name | Clusterin | | Chr Location | 8p21.1 | | NCBI Gene ID | 1115 | | OMIM ID | 185551 | | Ensembl ID | ENSG00000120885 | | UniProt ID | P10909 | | Encoded Protein | Clusterin (ApoJ) | | Associated Diseases | Alzheimer's disease, Huntington's disease, ALS, frontotemporal dementia |
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Function
CLU encodes clusterin, also known as apolipoprotein J (ApoJ), a multifunctional glycoprotein that is highly expressed in the brain. Clusterin participates in various physiological processes including lipid transport, complement regulation, and apoptosis.
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CLU Gene - Clusterin
Overview
Clusterin is a Chaperone protein involved in lipid transport, protein folding, and neurodegeneration. Associated with [Alzheimer's disease](/diseases/alzheimers-disease) and other age-related diseases.
title: CLU Gene [@bhattacharjee2011]
--- [@last2020]
CLU (Clusterin)
Introduction
Clu Gene Clusterin is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@sato2019]
| Property | Value | [@nonis2022] |----------|-------| [@kumar2021] | Gene Symbol | CLU | | Full Name | Clusterin | | Chr Location | 8p21.1 | | NCBI Gene ID | 1115 | | OMIM ID | 185551 | | Ensembl ID | ENSG00000120885 | | UniProt ID | P10909 | | Encoded Protein | Clusterin (ApoJ) | | Associated Diseases | Alzheimer's disease, Huntington's disease, ALS, frontotemporal dementia |
</div>
Function
CLU encodes clusterin, also known as apolipoprotein J (ApoJ), a multifunctional glycoprotein that is highly expressed in the brain. Clusterin participates in various physiological processes including lipid transport, complement regulation, and apoptosis.
Key normal physiological functions include:
Cholesterol transport - Lipoprotein particle formation and lipid homeostasis
The Allen Brain Atlas shows high CLU expression in:
Hippocampal pyramidal and granule cells
Cortical pyramidal neurons
Cerebellar Purkinje cells
Key Publications
[Harold et al., Clusterin and Alzheimer disease (2009)](https://doi.org/10.1016/j.ajhg.2009.12.004)
[DeMattos et al., Clusterin as Aβ chaperone (2002)](https://doi.org/10.1073/pnas.212641299)
[Miller et al., CLU variants and neurodegeneration (2013)](https://doi.org/10.1016/j.neurobiolaging.2012.11.026)
Background
The study of Clu Gene Clusterin has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
External Links
[PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
[Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
[Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data