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COQ5 Gene

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COQ5 Gene

Introduction

Coq5 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

COQ5 Gene (Coenzyme Q Biosynthesis Factor 5) provides instructions for making the COQ5 protein, a mitochondrial methyltransferase essential for coenzyme Q (CoQ10) biosynthesis. The COQ5 protein catalyzes the C5-methylation step in the CoQ biosynthetic pathway, converting demethoxy-ubiquinone (DMQ) to intermediate forms that are subsequently processed to produce ubiquinone (CoQ10). [@stefely2016]

Gene Information

<div class="infobox infobox-gene"> [@desbats2015]
<table> [@hargreaves2014]
<tr><th>Gene Symbol</th><td>COQ5</td></tr>
<tr><th>Full Name</th><td>Coenzyme Q Biosynthesis Factor 5</td></tr>
<tr><th>Chromosomal Location</th><td>12q24.31</td></tr>
<tr><th>NCBI Gene ID</th><td>84223</td></tr>
<tr><th>OMIM</th><td>616787</td></tr>
<tr><th>Ensembl ID</th><td>ENSG00000108465</td></tr>
<tr><th>UniProt ID</th><td>Q9NXK5</td></tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>
</div>

Gene Structure

The COQ5 gene contains:

  • Exons: 6 coding exons
  • Transcript length: ~1.2 kb coding sequence
  • Protein length: 333 amino acids
  • Molecular weight: ~38 kDa

Normal Function

CoQ10 Biosynthesis

COQ5 encodes a S-adenosylmethionine (SAM)-dependent methyltransferase that catalyzes:

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