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COQ7 Gene

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COQ7 Gene

Introduction

Coq7 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

COQ7 Gene (Coenzyme Q Biosynthesis Factor 7) provides instructions for making the COQ7 protein, also known as coenzyme Q7 or mitochondrial coenzyme Q hydroxylase. This enzyme catalyzes the 5-hydroxylation step in coenzyme Q (CoQ10) biosynthesis, converting demethoxy-ubiquinone (DMQ) to produce ubiquinone (CoQ10), the essential electron carrier in the mitochondrial respiratory chain. [@wang2016]

Gene Information

<div class="infobox infobox-gene"> [@zhang2017]
<table> [@hargreaves2014]
<tr><th>Gene Symbol</th><td>COQ7</td></tr>
<tr><th>Full Name</th><td>Coenzyme Q Biosynthesis Factor 7</td></tr>
<tr><th>Chromosomal Location</th><td>16p13.3</td></tr>
<tr><th>NCBI Gene ID</th><td>10277</td></tr>
<tr><th>OMIM</th><td>609697</td></tr>
<tr><th>Ensembl ID</th><td>ENSG00000109113</td></tr>
<tr><th>UniProt ID</th><td>Q9UQB8</td></tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>
</div>

Gene Structure

The COQ7 gene contains:

  • Exons: 5 coding exons
  • Transcript length: ~1.0 kb coding sequence
  • Protein length: 248 amino acids
  • Molecular weight: ~25 kDa

Normal Function

CoQ10 Biosynthesis

COQ7 encodes a diiron hydroxylase that catalyzes:

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