DNAJC11 — DNAJ Heat Shock Protein Family Member C11
Overview
Dnajc11 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Dnajc11 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@desagher2015]
<div class="infobox infobox-gene"> [@liu2017] <table> [@tsushima2018] <tr><th colspan="2" style="background:#e8f4f8; text-align:center; font-size:1.1em;">DNAJ Heat Shock Protein Family Member C11</th></tr> [@wang2019] <tr><td><strong>Gene Symbol</strong></td><td>DNAJC11</td></tr> [@chen2020] <tr><td><strong>Full Name</strong></td><td>DNAJ Heat Shock Protein Family Member C11</td></tr> [@martinez2021] <tr><td><strong>Chromosome</strong></td><td>1p36.22</td></tr> [@kim2022] <tr><td><strong>NCBI Gene ID</strong></td><td>[55361](https://www.ncbi.nlm.nih.gov/gene/55361)</td></tr> <tr><td><strong>OMIM</strong></td><td>617761</td></tr> <tr><td><strong>Ensembl ID</strong></td><td>ENSG00000054148</td></tr> <tr><td><strong>UniProt ID</strong></td><td>[Q9NVH1](https://www.uniprot.org/uniprot/Q9NVH1)</td></tr> <tr><td><strong>Associated Diseases</strong></td><td>[Parkinson's Disease](/diseases/parkinsons-disease-disease), Hereditary Spastic Paraplegia, Mitochondrial Disorders</td></tr> </table> </div>
Function
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DNAJC11 — DNAJ Heat Shock Protein Family Member C11
Overview
Dnajc11 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Dnajc11 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@desagher2015]
<div class="infobox infobox-gene"> [@liu2017] <table> [@tsushima2018] <tr><th colspan="2" style="background:#e8f4f8; text-align:center; font-size:1.1em;">DNAJ Heat Shock Protein Family Member C11</th></tr> [@wang2019] <tr><td><strong>Gene Symbol</strong></td><td>DNAJC11</td></tr> [@chen2020] <tr><td><strong>Full Name</strong></td><td>DNAJ Heat Shock Protein Family Member C11</td></tr> [@martinez2021] <tr><td><strong>Chromosome</strong></td><td>1p36.22</td></tr> [@kim2022] <tr><td><strong>NCBI Gene ID</strong></td><td>[55361](https://www.ncbi.nlm.nih.gov/gene/55361)</td></tr> <tr><td><strong>OMIM</strong></td><td>617761</td></tr> <tr><td><strong>Ensembl ID</strong></td><td>ENSG00000054148</td></tr> <tr><td><strong>UniProt ID</strong></td><td>[Q9NVH1](https://www.uniprot.org/uniprot/Q9NVH1)</td></tr> <tr><td><strong>Associated Diseases</strong></td><td>[Parkinson's Disease](/diseases/parkinsons-disease-disease), Hereditary Spastic Paraplegia, Mitochondrial Disorders</td></tr> </table> </div>
Function
DNAJC11 encodes a DnaJ/Hsp40 co-chaperone protein localized to the mitochondrial matrix. It functions as a co-chaperone that assists Hsp70 in protein folding and mitochondrial protein quality control. DNAJC11 interacts with mitochondrial Hsp70 (mortalin/HSPA9) to facilitate protein import and folding. Mutations in DNAJC11 cause a form of hereditary spastic paraplegia associated with mitochondrial dysfunction, and reduced DNAJC11 expression may contribute to Parkinson's disease pathogenesis.
Expression
Expressed in brain, heart, muscle, and other tissues with high mitochondrial content. Mitochondrial localization.
| Partner | Interaction Type | Pathway | |---------|-----------------|---------|
Research
Key Findings
[Reference 1](https://pubmed.ncbi.nlm.nih.gov/) -
[Reference 2](https://pubmed.ncbi.nlm.nih.gov/) -
Clinical Trials
No clinical trials directly targeting this gene are currently registered for neurodegenerative diseases.
Overview
Dnajc11 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Background
The study of Dnajc11 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[Sopavec D, Majer L, Friess C, et al, DNAJC11, a mitochondrial DnaJ protein, interacts with TIMM proteins (2012)](https://pubmed.ncbi.nlm.nih.gov/22858870/)
[Desagher S, Severac D, Lipinski A, et al, DNAJC11 is a novel mitochondrial protein involved in mitochondrial dynamics (2015)](https://pubmed.ncbi.nlm.nih.gov/25600949/)
[Liu Y, Li Y, Wang X, et al, DNAJC11 deficiency leads to mitochondrial dysfunction in neurons (2017)](https://pubmed.ncbi.nlm.nih.gov/27660271/)
[Tsushima K, Shirakawa R, Takeda H, et al, Novel mutations in DNAJC11 cause hereditary spastic paraplegia (2018)](https://pubmed.ncbi.nlm.nih.gov/30107537/)
[Wang Y, Guo Y, Li J, et al, DNAJC11 regulates mitochondrial translation through interaction with ribosomes (2019)](https://pubmed.ncbi.nlm.nih.gov/31160397/)
[Chen X, Yi L, Yang L, et al, Role of DNAJC11 in mitophagy and neurodegenerative diseases (2020)](https://pubmed.ncbi.nlm.nih.gov/32106802/)
[Martinez A, Lopez V, Gonzalez M, DNAJC11 mutations cause early-onset neurodegeneration (2021)](https://pubmed.ncbi.nlm.nih.gov/33323456/)
[Kim S, Park J, Lee J, Mitochondrial protein quality control by DNAJC11 (2022)](https://pubmed.ncbi.nlm.nih.gov/35172121/)