GRAMD1B Gene - GRAM Domain Containing 1B (GRAMD1B)

GRAMD1B Gene - GRAM Domain Containing 1B (GRAMD1B)

Introduction

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">GRAMD1B Gene - GRAM Domain Containing 1B (GRAMD1B)</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td><strong>GRADPS</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>GRAMD1B - GRAM Domain Containing 1B (GRAMD1B)</td>
</tr>
<tr>
<td class="label">Type</td>
<td>Gene</td>
</tr>
<tr>
<td class="label">NCBI</td>
<td><a href="https://www.ncbi.nlm.nih.gov/gene/?term=GRADPS" target="_blank">Search NCBI</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>

Gramd1B Gene Gram Domain Containing 1B (Gramd1B) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

[@lerma2010]
[@hu2009]

Overview

GRAMD1B (GRAM Domain Containing 1B), also known as GRAMD1B, encodes a protein involved in lipid homeostasis and autophagy regulation. The gene is located on chromosome 11q13.4 and encodes a protein of 762 amino acids. GRAMD1 proteins play emerging roles in cellular stress responses relevant to neurodegeneration. [@vincent2013]

Function

GRAMD1B participates in: [@matute2011]

GRAMD1B Gene - GRAM Domain Containing 1B (GRAMD1B)

Introduction

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">GRAMD1B Gene - GRAM Domain Containing 1B (GRAMD1B)</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td><strong>GRADPS</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>GRAMD1B - GRAM Domain Containing 1B (GRAMD1B)</td>
</tr>
<tr>
<td class="label">Type</td>
<td>Gene</td>
</tr>
<tr>
<td class="label">NCBI</td>
<td><a href="https://www.ncbi.nlm.nih.gov/gene/?term=GRADPS" target="_blank">Search NCBI</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>

Gramd1B Gene Gram Domain Containing 1B (Gramd1B) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

[@lerma2010]
[@hu2009]

Overview

GRAMD1B (GRAM Domain Containing 1B), also known as GRAMD1B, encodes a protein involved in lipid homeostasis and autophagy regulation. The gene is located on chromosome 11q13.4 and encodes a protein of 762 amino acids. GRAMD1 proteins play emerging roles in cellular stress responses relevant to neurodegeneration. [@vincent2013]

Function

GRAMD1B participates in: [@matute2011]

• Lipid droplet regulation: Localizes to lipid droplet membranes
• [Autophagy](/entities/autophagy) initiation: Interacts with autophagy machinery
• ER stress response: Modulates [unfolded protein response](/entities/unfolded-protein-response)
• Cholesterol trafficking: Affects cellular cholesterol distribution

• Cellular lipid homeostasis
• Membrane remodeling processes
• Protein aggregate clearance
• Neuronal survival under stress

Disease Associations

Alzheimer's Disease (AD)

• GRAMD1B expression altered in AD brain
• Affects lipid metabolism in [neurons](/entities/neurons)
• May influence [amyloid precursor protein](/entities/app-protein) processing
• Role in autophagy-lysosomal dysfunction

Parkinson's Disease (PD)

• Dysregulated in PD models
• Affects [alpha-synuclein](/mechanisms/alpha-synuclein) aggregation
• Modulates neuronal vulnerability to stress
• Potential therapeutic target

Huntington's Disease (HD)

• Altered expression in HD brain
• May affect mutant [huntingtin](/proteins/huntingtin-protein) aggregation
• Contributes to lipid dysregulation
• Autophagy modulation relevance

Amyotrophic Lateral Sclerosis (ALS)

• GRAMD1B variants in ALS patients
• Affects [TDP-43](/proteins/tdp-43) proteinopathy
• Modulates cellular stress responses
• Relevance to protein homeostasis

Frontotemporal Dementia (FTD)

• Altered lipid homeostasis in FTD
• GRAMD1B contributes to pathology
• Interaction with progranulin pathways

Expression Pattern

GRAMD1B is expressed in:

• Brain ([cortex](/brain-regions/cortex), [hippocampus](/brain-regions/hippocampus), cerebellum)
• Liver and adipose tissue
• Kidney and lung
• Immune cells (monocytes, macrophages)
• Neuronal cell lines

Molecular Mechanisms

Domain Structure

• GRAM domain: lipid-binding/regulatory
• VASt domain: membrane association
• PH-like domain: phosphoinositide binding

Interactions

• Binds phosphatidylinositol phosphates
• Associates with lipid droplets
• Interacts with autophagy proteins (ATG14, WIPI)
• Modulates mTORC1 signaling

Regulation

• Transcriptionally regulated by stress signals
• Post-translational modifications affect localization
• Lipid availability influences protein function
• Subcellular localization determines activity

Therapeutic Targeting

Small Molecule Approaches

• Lipid metabolism modulators
• Autophagy inducers
• ER stress reducers

Research Directions

• Understanding isoform-specific functions
• Developing targeted small molecules
• Gene therapy approaches
• Biomarker development

Key Publications

See Also

• [Lipid Metabolism](/mechanisms/lipid-metabolism)mechanisms/sphingolipid-metabolism)
• [Autophagy-Lysosomal Pathway](/mechanisms/autophagy-lysosomal-pathway)
• [ER Stress](/mechanisms/er-stress-neurodegeneration)
• [Alzheimer's Disease](/diseases/alzheimers-disease)
• [Parkinson's Disease](/diseases/parkinsons-disease)

External Links

• [NCBI Gene: GRAMD1B](https://www.ncbi.nlm.nih.gov/gene/54892)
• [UniProt: Q9Y282](https://www.uniprot.org/uniprot/Q9Y282)
• [GeneCards: GRAMD1B](https://www.genecards.org/cgi-bin/carddisp.pl?gene=GRAMD1B)

Background

The study of Gramd1B Gene Gram Domain Containing 1B (Gramd1B) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

See Also

• [Kainate Receptors](/kainate-receptors)
• [Glutamate Receptors](/glutamate-receptors)
• [GRIK Gene Family](/grik-gene-family)

External Links

• [GRIK6 Gene - NCBI](https://www.ncbi.nlm.nih.gov/gene/2905)

References