Homer2 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Homer2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@xiao1998]
Homer2 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Homer2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@xiao1998]
HOMER2 encodes Homer 2, a scaffolding protein that organizes postsynaptic density structures and regulates synaptic signaling. Homer proteins bind to group I metabotropic glutamate receptors (mGluR1/5), Shank proteins, and other synaptic components. Homer 2 is particularly important for mGluR5 signaling, calcium homeostasis, and synaptic plasticity. Reduced Homer 2 expression has been reported in Alzheimer's disease brains, contributing to disrupted glutamatergic signaling and synaptic dysfunction.
Expression
High expression in brain, particularly in the cerebral [cortex](/brain-regions/cortex), [hippocampus](/brain-regions/hippocampus), and cerebellum. Expressed in [neurons](/entities/neurons) at postsynaptic densities.
| Partner | Interaction Type | Pathway | |---------|-----------------|---------|
Research
Key Findings
[Reference 1](https://pubmed.ncbi.nlm.nih.gov/) -
[Reference 2](https://pubmed.ncbi.nlm.nih.gov/) -
Clinical Trials
No clinical trials directly targeting this gene are currently registered for neurodegenerative diseases.
Overview
Homer2 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Background
The study of Homer2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[Brakeman PR, Yuan SH, Kim JY, et al, Homer: a protein that selectively binds to group I metabotropic glutamate receptors (1997)](https://pubmed.ncbi.nlm.nih.gov/9069290/)
[Xiao B, Tu JC, Worley PF, Homer: a neuronal activity-regulated immediate early gene (1998)](https://pubmed.ncbi.nlm.nih.gov/9590165/)
[Tu JC, Xiao B, Naisbitt S, et al, Coupling of mGluR/Homer to NMDA receptors (1999)](https://pubmed.ncbi.nlm.nih.gov/10433268/)
[Rong R, Ahn CY, Huang H, et al, PI3K scaffolding by Homer (2003)](https://pubmed.ncbi.nlm.nih.gov/14572461/)
[Hayashi MK, Ames JB, Ikura M, Structure of Homer1/cain: a neuronal signaling scaffold (2005)](https://pubmed.ncbi.nlm.nih.gov/16105641/)