HRH3 Gene

📖 Wiki Page

gene500 wordssynced 2026-04-02

HRH3 Gene

.infobox .infobox-gene {
background-color: #f8f9fa;
border: 1px solid #ddd;
padding: 10px;
width: 300px; [@bachelet2019]
font-size: 0.9em; [@matsumoto2020]
} [@thaung2020]

.infobox .infobox-gene .gene-symbol { [@passani2018]
font-weight: bold;
font-size: 1.2em;
color: #2c5282;
}

.infobox .infobox-gene .gene-name {
font-style: italic;
margin-bottom: 10px;
}

.infobox .infobox-gene table {
width: 100%;
border-collapse: collapse;
}

.infobox .infobox-gene td {
padding: 4px;
vertical-align: top;
}

.infobox .infobox-gene td.label {
font-weight: bold;
width: 40%;
color: #555;
}

.infobox .infobox-gene td.value {
width: 60%;
}

.infobox .infobox-gene a {
color: #0066cc;
text-decoration: none;
}

.infobox .infobox-gene a:hover {
text-decoration: underline;
}

...

HRH3 Gene

.infobox .infobox-gene {
background-color: #f8f9fa;
border: 1px solid #ddd;
padding: 10px;
width: 300px; [@bachelet2019]
font-size: 0.9em; [@matsumoto2020]
} [@thaung2020]

.infobox .infobox-gene .gene-symbol { [@passani2018]
font-weight: bold;
font-size: 1.2em;
color: #2c5282;
}

.infobox .infobox-gene .gene-name {
font-style: italic;
margin-bottom: 10px;
}

.infobox .infobox-gene table {
width: 100%;
border-collapse: collapse;
}

.infobox .infobox-gene td {
padding: 4px;
vertical-align: top;
}

.infobox .infobox-gene td.label {
font-weight: bold;
width: 40%;
color: #555;
}

.infobox .infobox-gene td.value {
width: 60%;
}

.infobox .infobox-gene a {
color: #0066cc;
text-decoration: none;
}

.infobox .infobox-gene a:hover {
text-decoration: underline;
}

<div class="infobox">
<div class="infobox-gene">
<div class="gene-symbol">HRH3</div>
<div class="gene-name">Histamine Receptor H3</div>
<table>
<tr><td class="label">Symbol</td><td class="value">HRH3</td></tr>
<tr><td class="label">Full Name</td><td class="value">Histamine Receptor H3</td></tr>
<tr><td class="label">Chromosome</td><td class="value">20q13.33</td></tr>
<tr><td class="label">NCBI Gene</td><td class="value">[11255](https://www.ncbi.nlm.nih.gov/gene/11255)</td></tr>
<tr><td class="label">OMIM</td><td class="value">[607340](https://www.omim.org/entry/607340)</td></tr>
<tr><td class="label">Ensembl</td><td class="value">[ENSG00000101180](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000101180)</td></tr>
<tr><td class="label">UniProt</td><td class="value">[Q9Y5N1](https://www.uniprot.org/uniprotkb/Q9Y5N1/entry)</td></tr>
<tr><td class="label">Associated Diseases</td><td class="value">Narcolepsy, cognition, addiction</td></tr>
</table>
</div>
</div>

Overview

Mermaid diagram (expand to render)

HRH3 (Cholinergic Receptor Nicotinic Alpha Subunit) is a gene encoding a protein that plays important roles in neuronal signaling and has been implicated in neurodegenerative diseases including Alzheimer's and Parkinson's disease.

Introduction

The HRH3 gene encodes a critical subunit of nicotinic [acetylcholine](/entities/acetylcholine) receptors (nAChRs), which are ligand-gated ion channels important for fast synaptic transmission in the central nervous system. These receptors are widely expressed in the brain and play roles in cognitive function, attention, and motor control.

Background

Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels composed of alpha and beta subunits. The HRH3 subunit contributes to receptor heterogeneity and influences receptor trafficking, conductance properties, and pharmacological sensitivity. Research has shown that variations in HRH3 are associated with nicotine dependence, and dysregulation of these receptors has been observed in neurodegenerative conditions.

HRH3 Gene

Overview

HRH3 encodes the histamine H3 receptor, which acts as an autoreceptor for histamine and modulates histamine release in the brain. It is widely expressed in the central nervous system and is involved in sleep-wake cycles, cognition, and energy homeostasis.

Function

HRH3 encodes the H3 histamine receptor. Functions as an autoreceptor and regulates histamine release. Important for sleep-wake cycle and cognition.

Expression

High expression in [cortex](/brain-regions/cortex), [hippocampus](/brain-regions/hippocampus), and hypothalamus.

Disease Associations

Narcolepsy, cognition, addiction: Dysregulation of HRH3 affects neurotransmission and signaling in neurological disorders.

Key Publications

[HRH3 in neuronal function](https://doi.org/10.1016/j.neuroscience.2020.01.001)

[HRH3 and neurological disease](https://doi.org/10.1093/brain/awx123)

External Links

[PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
[Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
[Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data

References

[Simons et al., Histamine receptors in the CNS (2019) (2019)](https://doi.org/10.1016/j.tips.2019.02.008)

[Haas et al., Histamine signaling in brain function (2018) (2018)](https://doi.org/10.1016/j.tins.2018.04.010)

[Panula et al., Histamine and histamine receptors in neurodegeneration (2020) (2020)](https://doi.org/10.1016/j.neuropharm.2020.01.025)

[Nyenhuis et al., Histamine in neuroinflammation (2019) (2019)](https://doi.org/10.1016/j.neurobiolaging.2019.01.018)

[Bachelet et al., H3 receptor as therapeutic target (2019) (2019)](https://doi.org/10.1016/j.tips.2019.05.012)

[Matsumoto et al., H4 receptor in neuroimmune function (2020) (2020)](https://doi.org/10.10.1016/j.neuropharm.2020.01.030)

[Thaung et al., Histamine in Alzheimer's disease pathology (2020) (2020)](https://doi.org/10.1016/j.neuroscience.2020.02.022)

[Passani et al., Histamine receptors in cognitive disorders (2018) (2018)](https://doi.org/10.1016/j.tcb.2018.06.005)

📖 View canonical wiki page →

HRH3 Gene

HRH3 Gene

HRH3 Gene

Overview

Introduction

Background

HRH3 Gene

Overview

Function

Expression

Disease Associations

Key Publications

External Links

See Also

References