Htr1B Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Attribute | Value | |-----------|-------| | Gene Symbol | HTR1B | | Full Name | 5-Hydroxytryptamine Receptor 1B | | Chromosomal Location | 6q14.2 | | NCBI Gene ID | [3351](https://www.ncbi.nlm.nih.gov/gene/3351) | | Ensembl ID | ENSG00000149212 | | UniProt ID | [P28222](https://www.uniprot.org/uniprot/P28222) | | Gene Family | 5-HT1 receptor family (GPCR) | | Protein Class | G protein-coupled receptor | | Brain Expression | Basal Ganglia, Cortex, Hippocampus |
</div>}
Overview
The HTR1B gene encodes the 5-hydroxytryptamine receptor 1B (5-HT1B), an inhibitory G protein-coupled receptor (GPCR) that functions as both an autoreceptor regulating serotonin release and a heteroreceptor modulating other neurotransmitters. This receptor is widely expressed in the brain and plays key roles in mood regulation, aggression, impulsivity, and various neuropsychiatric disorders.
Htr1B Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Attribute | Value | |-----------|-------| | Gene Symbol | HTR1B | | Full Name | 5-Hydroxytryptamine Receptor 1B | | Chromosomal Location | 6q14.2 | | NCBI Gene ID | [3351](https://www.ncbi.nlm.nih.gov/gene/3351) | | Ensembl ID | ENSG00000149212 | | UniProt ID | [P28222](https://www.uniprot.org/uniprot/P28222) | | Gene Family | 5-HT1 receptor family (GPCR) | | Protein Class | G protein-coupled receptor | | Brain Expression | Basal Ganglia, Cortex, Hippocampus |
</div>}
Overview
The HTR1B gene encodes the 5-hydroxytryptamine receptor 1B (5-HT1B), an inhibitory G protein-coupled receptor (GPCR) that functions as both an autoreceptor regulating serotonin release and a heteroreceptor modulating other neurotransmitters. This receptor is widely expressed in the brain and plays key roles in mood regulation, aggression, impulsivity, and various neuropsychiatric disorders.
PMID: 8365623(https://pubmed.ncbi.nlm.nih.gov/8365623/) - 5-HT1B receptor in aggression
PMID: 10618706(https://pubmed.ncbi.nlm.nih.gov/10618706/) - Serotonin in PD
Background
The study of Htr1B Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.