Htr1D Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Attribute | Value | [@moret2001] |-----------|-------| | Gene Symbol | HTR1D | | Full Name | 5-Hydroxytryptamine Receptor 1D | | Chromosomal Location | 1p36.12 | | NCBI Gene ID | [3352](https://www.ncbi.nlm.nih.gov/gene/3352) | | Ensembl ID | ENSG00000168594 | | UniProt ID | [P28221](https://www.uniprot.org/uniprot/P28221) | | Gene Family | 5-HT1 receptor family (GPCR) | | Protein Class | G protein-coupled receptor | | Expression | CNS, trigeminal nerve, cranial blood vessels |
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Overview
The HTR1D gene encodes the 5-hydroxytryptamine receptor 1D (5-HT1D), a G protein-coupled receptor that plays a critical role in migraine pathophysiology. This receptor is the primary target of triptan-class antimigraine drugs and regulates neurotransmitter release in the trigeminovascular system.
Gene Structure and Protein
The HTR1D gene is located on chromosome 1p36.12 and encodes a 377-amino acid protein. The receptor contains seven transmembrane domains typical of GPCRs and couples to Gi/o proteins, inhibiting adenylate cyclase and reducing cAMP production.
Expression Pattern
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HTR1D Gene, 5-Hydroxytryptamine Receptor 1D
Introduction
Htr1D Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Attribute | Value | [@moret2001] |-----------|-------| | Gene Symbol | HTR1D | | Full Name | 5-Hydroxytryptamine Receptor 1D | | Chromosomal Location | 1p36.12 | | NCBI Gene ID | [3352](https://www.ncbi.nlm.nih.gov/gene/3352) | | Ensembl ID | ENSG00000168594 | | UniProt ID | [P28221](https://www.uniprot.org/uniprot/P28221) | | Gene Family | 5-HT1 receptor family (GPCR) | | Protein Class | G protein-coupled receptor | | Expression | CNS, trigeminal nerve, cranial blood vessels |
</div>}
Overview
The HTR1D gene encodes the 5-hydroxytryptamine receptor 1D (5-HT1D), a G protein-coupled receptor that plays a critical role in migraine pathophysiology. This receptor is the primary target of triptan-class antimigraine drugs and regulates neurotransmitter release in the trigeminovascular system.
Gene Structure and Protein
The HTR1D gene is located on chromosome 1p36.12 and encodes a 377-amino acid protein. The receptor contains seven transmembrane domains typical of GPCRs and couples to Gi/o proteins, inhibiting adenylate cyclase and reducing cAMP production.
Expression Pattern
5-HT1D receptors are expressed in:
Trigeminal ganglion - Primary site for migraine pain
Cranial blood vessels - Cerebral and meningeal arteries
The study of Htr1D Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Pathway & Interaction Diagram
Interactive diagram showing HTR1D's key relationships in the SciDEX knowledge graph (6 connections shown).
[Weinshank RL, Zgombick JM, MacKenzie DM, et al, The human 5-HT1D receptor is encoded by a 5-HT1D alpha and 5-HT1D beta gene subfamily (1992)](https://pubmed.ncbi.nlm.nih.gov/2473539/)
[Humphrey PP, Feniuk W, Perren MJ, et al, The pharmacology of the novel 5-HT1-like receptor that mediates the vasoconstriction in human cerebral vessels (1991)](https://pubmed.ncbi.nlm.nih.gov/7848904/)
[Moret C, Briley M, The importance of serotonin in neuropsychiatry (2001)](https://pubmed.ncbi.nlm.nih.gov/10625477/)