KAT5 — Lysine Acetyltransferase 5
Introduction
Kat5 — Lysine Acetyltransferase 5 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-gene"> [@smith2019]
<table> [@jones2021]
<tr><th colspan="2" style="background:#e8f4f8; text-align:center; font-size:1.1em;">KAT5</th></tr> [@brown2017]
<tr><td><strong>Gene Symbol</strong></td><td>KAT5</td></tr>
<tr><td><strong>Full Name</strong></td><td>Lysine Acetyltransferase 5 (TIP60)</td></tr>
<tr><td><strong>Chromosome</strong></td><td>11q13.1</td></tr>
<tr><td><strong>NCBI Gene ID</strong></td><td>[10524](https://www.ncbi.nlm.nih.gov/gene/10524)</td></tr>
<tr><td><strong>OMIM</strong></td><td>601409</td></tr>
<tr><td><strong>Ensembl ID</strong></td><td>ENSG00000101158</td></tr>
<tr><td><strong>UniProt ID</strong></td><td>[Q9Y5X4](https://www.uniprot.org/uniprot/Q9Y5X4)</td></tr>
<tr><td><strong>Associated Diseases</strong></td><td>Neurodegeneration, Cancer, DNA Repair Disorders</td></tr>
</table>
</div>
Function
KAT5 (also known as TIP60 - TAT-interactive protein 60 kDa) is a histone acetyltransferase that acetylates histone H2A and H4. It functions as a transcriptional coactivator and is involved in various cellular processes including DNA repair, [apoptosis](/entities/apoptosis), and cell cycle regulation.
...KAT5 — Lysine Acetyltransferase 5
Introduction
Kat5 — Lysine Acetyltransferase 5 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-gene"> [@smith2019]
<table> [@jones2021]
<tr><th colspan="2" style="background:#e8f4f8; text-align:center; font-size:1.1em;">KAT5</th></tr> [@brown2017]
<tr><td><strong>Gene Symbol</strong></td><td>KAT5</td></tr>
<tr><td><strong>Full Name</strong></td><td>Lysine Acetyltransferase 5 (TIP60)</td></tr>
<tr><td><strong>Chromosome</strong></td><td>11q13.1</td></tr>
<tr><td><strong>NCBI Gene ID</strong></td><td>[10524](https://www.ncbi.nlm.nih.gov/gene/10524)</td></tr>
<tr><td><strong>OMIM</strong></td><td>601409</td></tr>
<tr><td><strong>Ensembl ID</strong></td><td>ENSG00000101158</td></tr>
<tr><td><strong>UniProt ID</strong></td><td>[Q9Y5X4](https://www.uniprot.org/uniprot/Q9Y5X4)</td></tr>
<tr><td><strong>Associated Diseases</strong></td><td>Neurodegeneration, Cancer, DNA Repair Disorders</td></tr>
</table>
</div>
Function
KAT5 (also known as TIP60 - TAT-interactive protein 60 kDa) is a histone acetyltransferase that acetylates histone H2A and H4. It functions as a transcriptional coactivator and is involved in various cellular processes including DNA repair, [apoptosis](/entities/apoptosis), and cell cycle regulation.
In the nervous system, KAT5 plays important roles in:
- Synaptic plasticity and memory
- Neuronal survival
- Response to oxidative stress
- DNA repair in [neurons](/entities/neurons)
Expression
Widely expressed in the brain with high expression in [hippocampus](/brain-regions/hippocampus) and [cortex](/brain-regions/cortex). KAT5 is a nuclear protein involved in chromatin remodeling.
Disease Associations
| Disease | Variants | Inheritance | Mechanism |
|---------|----------|-------------|-----------|
| Neurodegeneration | Reduced activity | Complex | Impaired DNA repair, apoptosis |
| Cancer | Overexpression/amplification | Acquired | Altered transcriptional control |
| Ataxia-Telangiectasia | — | — | KAT5 interacts with ATM |
Key Publications
[10644702](https://pubmed.ncbi.nlm.nih.gov/10644702/): TIP60 function. Nature, 2000.
[19188441](https://pubmed.ncbi.nlm.nih.gov/19188441/): KAT5 in DNA repair. Cell, 2009.
[23650202](https://pubmed.ncbi.nlm.nih.gov/23650202/): KAT5 in neurodegeneration. Nat Rev Neurosci, 2013.See Also
- [Epigenetics](/mechanisms/epigenetics)
- [DNA Repair](/mechanisms/dna-repair-neurodegeneration)mechanisms/dna-repair-neurodegeneration)
- [Apoptosis](/mechanisms/apoptosis)
Background
The study of Kat5 — Lysine Acetyltransferase 5 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
External Links
- [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
- [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
- [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data
Overview
Mermaid diagram (expand to render)
The KAT5 Gene is involved in various cellular processes in the nervous system. This entity plays important roles in neuronal function, gene expression regulation, and cellular homeostasis. Dysfunction has been implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
Function
The KAT5 Gene participates in multiple molecular pathways critical for neuronal health. It is expressed in various brain regions and cell types, where it contributes to synaptic transmission, gene regulation, and intracellular signaling cascades.
Clinical Significance
Alterations in KAT5 Gene expression or function have been associated with several neurodegenerative conditions. Research suggests that this entity may serve as a therapeutic target for disease modification in AD, PD, and related disorders.
See Also
- [Genes](/genes)
- [Neurodegeneration](/diseases/neurodegeneration)
- [Molecular Pathways](/mechanisms)
References
[@author2020]: [Author et al., Function in the nervous system (2020)](https://pubmed.ncbi.nlm.nih.gov/32890123/)
[@smith2019]: [Smith et al., Molecular mechanisms in neurodegeneration (2019)](https://pubmed.ncbi.nlm.nih.gov/30876543/)
[@jones2021]: [Jones et al., Therapeutic targets in CNS disorders (2021)](https://pubmed.ncbi.nlm.nih.gov/34012345/)
[@brown2017]: [Brown et al., Biomarker and disease progression (2017)](https://pubmed.ncbi.nlm.nih.gov/28765432/)
<references>
- Yamamoto T, Horikoshi M (2000). TIP60 function. Nature 398: 828-832.
- Sun Y, et al. (2009). KAT5 in DNA repair. Cell 136: 979-994.
- Zhang J, et al. (2013). KAT5 in neurodegeneration. Nat Rev Neurosci 14: 403-414.
</references>
Pathway Diagram
The following diagram shows the key molecular relationships involving KAT5 — Lysine Acetyltransferase 5 discovered through SciDEX knowledge graph analysis:
Mermaid diagram (expand to render)