Kcna4 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Overview
KCNA4 (Potassium Voltage-Gated Channel Subfamily A Member 4) encodes the Kv1.4 subunit, a voltage-gated potassium channel protein that forms part of the delayed rectifier potassium channel complex. This gene is located on chromosome 11q14.1 and encodes a protein of 653 amino acids with a molecular weight of approximately 73 kDa. [@misonou2005]
Gene Information
Protein Structure
The Kv1.4 protein is a member of the voltage-gated potassium channel (Kv) family and contains:
Kcna4 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Overview
KCNA4 (Potassium Voltage-Gated Channel Subfamily A Member 4) encodes the Kv1.4 subunit, a voltage-gated potassium channel protein that forms part of the delayed rectifier potassium channel complex. This gene is located on chromosome 11q14.1 and encodes a protein of 653 amino acids with a molecular weight of approximately 73 kDa. [@misonou2005]
Gene Information
Protein Structure
The Kv1.4 protein is a member of the voltage-gated potassium channel (Kv) family and contains:
Six transmembrane domains (S1-S6)
Voltage sensor domain (S1-S4) that detects membrane potential changes
Pore region (S5-S6) that forms the ion conduction pathway
N-terminal domain containing inactivation ball peptide for fast inactivation
Tetramerization domain (T1) in the N-terminus for subunit assembly
Normal Function
In the nervous system, Kv1.4 channels play crucial roles in:
Stocker M, et al. (1999). "Subunit assembly of the voltage-gated potassium channel Kv1.4." J Biol Chem. PMID: 10357815(https://pubmed.ncbi.nlm.nih.gov/10357815/)
Misonou H, et al. (2005). "Kv1.4 subunit: a key molecule for neuronal vulnerability." ScientificWorldJournal. PMID: 15772204(https://pubmed.ncbi.nlm.nih.gov/15772204/)
Vacher H, et al. (2008). "Voltage-gated potassium channels: a structural overview." Adv Exp Med Biol. PMID: 19157088(https://pubmed.ncbi.nlm.nih.gov/19157088/)
The study of Kcna4 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
References
[Stocker M, et al, (1999) (1999)](https://pubmed.ncbi.nlm.nih.gov/10357815/)
[Misonou H, et al, (2005) (2005)](https://pubmed.ncbi.nlm.nih.gov/15772204/)
[Vacher H, et al, (2008) (2008)](https://pubmed.ncbi.nlm.nih.gov/19157088/)
[Grupe A, et al, (1990) (1990)](https://pubmed.ncbi.nlm.nih.gov/2157599/)
[Deal KK, et al, (1994) (1994)](https://pubmed.ncbi.nlm.nih.gov/7909236/)
[Song WJ, et al, (1998) (1998)](https://pubmed.ncbi.nlm.nih.gov/9602103/)
[Rho JM, et al, (1999) (1999)](https://pubmed.ncbi.nlm.nih.gov/10214147/)
[Coetzee WA, et al, (1999) (1999)](https://pubmed.ncbi.nlm.nih.gov/10414276/)