<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">KCNC1 Gene</th>
</tr>
<tr>
<td class="label">Gene Symbol</td>
<td>KCNC1</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>Potassium Voltage-Gated Channel Subfamily C Member 1</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>11p15.5</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>3749</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000129128</td>
</tr>
<tr>
<td class="label">UniProt</td>
<td>P48547</td>
</tr>
<tr>
<td class="label">Disease</td>
<td>Association Type</td>
</tr>
<tr>
<td class="label">Epilepsy</td>
<td>Causative</td>
</tr>
<tr>
<td class="label">Autism Spectrum Disorder</td>
<td>Risk Modulator</td>
</tr>
<tr>
<td class="label">Alzheimer's Disease</td>
<td>Risk Modulator</td>
</tr>
<tr>
<td class="label">Schizophrenia</td>
<td>Risk Modifier</td>
</tr>
<tr>
<td class="label">Compound</td>
<td>Type</td>
</tr>
<tr>
<td class="label">Autism compound</td>
<td>Enhancer</td>
</tr>
<tr>
<td class="label">Retigabine</td>
<td>Small molecule</td>
</tr>
<tr>
<td class="label">Strategy</td>
<td>Target</td>
</tr>
<tr>
<td class="label">Openers</td>
<td>Kv3.1 channels</td>
</tr>
<tr>
<td class="label">Gene therapy</td>
<td>Restore expression</td>
</tr>
<tr>
<td class="label">Modulators</td>
<td>Channel function</td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>
Kcnc1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Kcnc1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@muona2015]
KCNC1 (Potassium Voltage-Gated Channel Subfamily C Member 1) encodes the Kv3.1 potassium channel, a high-voltage activated potassium channel critical for fast-spiking [neurons](/entities/neurons). [@lau2000]
The KCNC1 gene encodes the Kv3.1 potassium channel subunit, a member of the Shaw-like subfamily of voltage-gated potassium channels. Kv3.1 is characterized by:
KCNC1 shows selective expression:
Kv3.1 modulators are being developed:
Kcnc1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Kcnc1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
KCNC1 encodes Kv3.1, a voltage-gated potassium channel with high expression in:
Kv3.1 channels support:
Kv3.1 dysfunction contributes to epilepsy:
In AD, KCNC1 alterations affect:
Channel mutations cause cerebellar ataxia: