KCNC4 Gene

KCNC4 Gene

Overview

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">KCNC4 Gene</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td><strong>KCNC4</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>KCNC4</td>
</tr>
<tr>
<td class="label">Type</td>
<td>Gene</td>
</tr>
<tr>
<td class="label">NCBI</td>
<td><a href="https://www.ncbi.nlm.nih.gov/gene/?term=KCNC4" target="_blank">Search NCBI</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>

Kcnc4 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Introduction

Kcnc4 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@martina2003]

Symbol: KCNC4 [@goldberg2005] Name: Potassium Voltage-Gated Channel Subfamily C Member 4 [@baranauskas2003] Chromosomal Location: 19q13.3 [@weiser1994] NCBI Gene ID: 3749 Ensembl ID: ENSG00000165682 UniProt: Q9UQE8

Gene Overview

KCNC4 Gene

Overview

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">KCNC4 Gene</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td><strong>KCNC4</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>KCNC4</td>
</tr>
<tr>
<td class="label">Type</td>
<td>Gene</td>
</tr>
<tr>
<td class="label">NCBI</td>
<td><a href="https://www.ncbi.nlm.nih.gov/gene/?term=KCNC4" target="_blank">Search NCBI</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>

Kcnc4 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Introduction

Kcnc4 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@martina2003]

Symbol: KCNC4 [@goldberg2005] Name: Potassium Voltage-Gated Channel Subfamily C Member 4 [@baranauskas2003] Chromosomal Location: 19q13.3 [@weiser1994] NCBI Gene ID: 3749 Ensembl ID: ENSG00000165682 UniProt: Q9UQE8

Gene Overview

KCNC4 (also known as Kv3.4 or KSHIIIC) encodes a voltage-gated potassium channel alpha subunit. The protein forms functional homomeric or heteromeric channels that conduct rapidly activating and inactivating potassium currents. KCNC4 is expressed predominantly in the central nervous system, particularly in the hippocampus, cerebral [cortex](/brain-regions/cortex), cerebellum, and brainstem auditory nuclei.

Normal Function

The KCNC4 gene encodes the Kv3.4 potassium channel, which is critical for high-frequency neuronal firing. These channels enable [neurons](/entities/neurons) to fire at very high frequencies (up to 500-800 Hz) without adaptation, which is essential for precise temporal coding in auditory and cerebellar circuits. In the hippocampus, Kv3.4 channels regulate the firing properties of pyramidal neurons and interneurons. The channels contribute to membrane repolarization, action potential duration, and the afterhyperpolarization phase.

Disease Associations

Spinocerebellar Ataxia (SCA)

Epilepsy

Alzheimer's Disease

Hearing Disorders

Expression Pattern

KCNC4 shows highest expression in:

• [Hippocampus](/brain-regions/hippocampus) (CA1-CA3 pyramidal neurons)
• Cerebral cortex (layer 2/3 and layer 5 pyramidal neurons)
• Cerebellar Purkinje cells
• Inferior colliculus
• Cochlear nuclei
• Brainstem auditory nuclei

Therapeutic Implications

Kv3.4 channels are being explored as therapeutic targets for:

• Cerebellar ataxias
• Epilepsy
• Auditory processing disorders
• Cognitive enhancement

Key Publications

See Also

• [KCNC4 Protein](/proteins/kcnc4-protein)
• [KCNC3 Gene](/proteins/kcnc3-protein)
• Potassium Channels
• [Spinocerebellar Ataxias](/diseases/spinocerebellar-ataxia)

External Links

• [NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/3749)
• [UniProt](https://www.uniprot.org/uniprot/Q9UQE8)
• [GeneCards](https://www.genecards.org/cgi-bin/carddisp.pl?gene=KCNC4)
• [OMIM](https://www.omim.org/entry/605268)

Overview

Kcnc4 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Background

The study of Kcnc4 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

References