Kif5C Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
--- [@brown2019] title: KIF5C Gene [@wilson2021] description: KIF5C is a neuron-specific kinesin heavy chain that functions in axonal transport. It is highly expr... [@anderson2018] tags: gene, neurodegeneration, axonal transport, kinesin, hereditary spastic paraplegia [@thompson2022] --- [@garcia2019]
Kif5C Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
--- [@brown2019] title: KIF5C Gene [@wilson2021] description: KIF5C is a neuron-specific kinesin heavy chain that functions in axonal transport. It is highly expr... [@anderson2018] tags: gene, neurodegeneration, axonal transport, kinesin, hereditary spastic paraplegia [@thompson2022] --- [@garcia2019]
KIF5C (Kinesin Family Member 5C) is a neuron-specific kinesin heavy chain that functions in axonal transport. It is highly expressed in brain, particularly in cortical [neurons](/entities/neurons). KIF5C, along with KIF5A, is the main kinesin-1 isoform in neurons. Mutations in KIF5C cause intellectual disability and cortical malformations, highlighting its critical role in neuronal development and connectivity.
Function
KIF5C is a neuron-specific kinesin heavy chain that functions in axonal transport. It is highly expressed in brain, particularly in cortical neurons. KIF5C, along with KIF5A, is the main kinesin-1 isoform in neurons. Mutations in KIF5C cause intellectual disability and cortical malformations, highlighting its critical role in neuronal development and connectivity.
Axonal Transport in Neurodegeneration
Axonal transport is essential for maintaining neuronal health. Defects in kinesin-mediated transport are implicated in:
Hereditary Spastic Paraplegia (HSP): Mutations in KIF1A, KIF5A cause HSP
The study of Kif5C Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Brain Atlas Resources
Allen Human Brain Atlas: [Expression data for KIF5C](https://human.brain-map.org/microarray/search/show?search_term=KIF5C)
Allen Cell Type Atlas: [Cell type expression data](https://celltype.brain-map.org/)