MET - MET Proto-Oncogene, Receptor Tyrosine Kinase

MET Gene — MET Proto-Oncogene, Receptor Tyrosine Kinase

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">MET - MET Proto-Oncogene, Receptor Tyrosine Kinase</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td>MET</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>MET Proto-Oncogene, Receptor Tyrosine Kinase</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>7q31.2</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>4233</td>
</tr>
<tr>
<td class="label">OMIM ID</td>
<td>164860</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000105976</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>P08581</td>
</tr>
<tr>
<td class="label">Protein Size</td>
<td>1390 amino acids</td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>~140 kDa (precursor), ~170 kDa (mature)</td>
</tr>
<tr>
<td class="label">Pathway</td>
<td>Function</td>
</tr>
<tr>
<td class="label">PI3K/AKT</td>
<td>Cell survival, growth</td>
</tr>
<tr>
<td class="label">MAPK/ERK</td>
<td>Proliferation, differentiation</td>
</tr>
<tr>
<td class="label">STAT</td>
<td>Transcription regulation</td>
</tr>
<tr>
<td class="label">PLCγ</td>
<td>Calcium signaling</td>
</tr>
<tr>
<td class="label">Drug</td>
<td>Mechanism</td>
</tr>
<tr>
<td class="label">Crizotinib</td>
<td>MET inhibitor</td>
</tr>
<tr>
<td

MET Gene — MET Proto-Oncogene, Receptor Tyrosine Kinase

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">MET - MET Proto-Oncogene, Receptor Tyrosine Kinase</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td>MET</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>MET Proto-Oncogene, Receptor Tyrosine Kinase</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>7q31.2</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>4233</td>
</tr>
<tr>
<td class="label">OMIM ID</td>
<td>164860</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000105976</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>P08581</td>
</tr>
<tr>
<td class="label">Protein Size</td>
<td>1390 amino acids</td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>~140 kDa (precursor), ~170 kDa (mature)</td>
</tr>
<tr>
<td class="label">Pathway</td>
<td>Function</td>
</tr>
<tr>
<td class="label">PI3K/AKT</td>
<td>Cell survival, growth</td>
</tr>
<tr>
<td class="label">MAPK/ERK</td>
<td>Proliferation, differentiation</td>
</tr>
<tr>
<td class="label">STAT</td>
<td>Transcription regulation</td>
</tr>
<tr>
<td class="label">PLCγ</td>
<td>Calcium signaling</td>
</tr>
<tr>
<td class="label">Drug</td>
<td>Mechanism</td>
</tr>
<tr>
<td class="label">Crizotinib</td>
<td>MET inhibitor</td>
</tr>
<tr>
<td class="label">Cabozantinib</td>
<td>Multi-kinase inhibitor</td>
</tr>
<tr>
<td class="label">Tepotinib</td>
<td>Selective MET inhibitor</td>
</tr>
<tr>
<td class="label">AMG 208</td>
<td>MET inhibitor</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/ad" style="color:#ef9a9a">AD</a>, <a href="/wiki/ali" style="color:#ef9a9a">ALI</a>, <a href="/wiki/als" style="color:#ef9a9a">ALS</a>, <a href="/wiki/ami" style="color:#ef9a9a">AMI</a>, <a href="/wiki/aging" style="color:#ef9a9a">Aging</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">479 edges</a></td>
</tr>
</table>

Pathway Diagram

Introduction

The MET gene (MET Proto-Oncogene, Receptor Tyrosine Kinase) encodes the hepatocyte growth factor receptor (HGFR), a receptor tyrosine kinase that plays crucial roles in cell growth, survival, migration, and tissue morphogenesis. In the nervous system, MET signaling is important for neuronal development, migration, and synaptic plasticity, and is implicated in neurodegenerative diseases and brain cancers[@maina2001].

Gene Information

Protein Structure

MET is a heterodimeric receptor:

• α-subunit ( extracellular): Ligand binding
• β-subunit (transmembrane): Contains tyrosine kinase domain
• Semaphorin (Sema) domain: HGF binding
• Tyrosine Kinase Domain: Catalytic activity (Y1234, Y1235)
• C-terminal Docking Sites: Multiple tyrosine residues for signaling

Normal Neuronal Function

Brain Development

• Neuronal Migration: Critical for cortical neuron migration
• Axon Guidance: Directs axon growth cones
• Dendritic Arborization: Promotes dendrite outgrowth
• Synapse Formation: Regulates synaptic development

Plasticity and Repair

• Synaptic Plasticity: Involved in learning and memory
• Neurogenesis: Regulates neural stem cell function
• Axon Regeneration: Promotes regeneration after injury

Astrocyte Function

• Astrocyte Development: Important for astrocyte maturation
• Glial Support: Supports neuronal survival

Expression Pattern

MET is expressed in various tissues:

• Brain: Neurons, astrocytes, neural progenitor cells
• Liver, kidney, muscle
• Endothelial cells
• Epithelial cells

Disease Associations

Alzheimer's Disease

• Synaptic Dysfunction: Altered MET signaling in AD brain
• Aβ Interaction: Amyloid-beta affects MET signaling
• Cognitive Decline: Linked to memory deficits

Parkinson's Disease

• Dopaminergic Neurons: MET in substantia nigra
• Neuroprotection: HGF/MET signaling is neuroprotective
• Therapeutic Potential: MET agonists being explored

Brain Cancer

• Oncogenic Role: MET amplification in glioblastoma
• Invasion: Promotes tumor cell invasion
• Therapeutic Target: MET inhibitors in clinical trials

Autism Spectrum Disorders

• Genetic Associations: MET variants linked to ASD risk
• Synaptic Function: Altered cortical connectivity

Signaling Pathways

MET activates multiple downstream pathways:

Therapeutic Targeting

See Also

• [HGF Gene](/genes/hgf)
• [Receptor Tyrosine Kinase Signaling](/mechanisms/receptor-tyrosine-kinase-signaling)
• [Alzheimer's Disease](/diseases/alzheimers-disease)
• [Parkinson's Disease](/diseases/parkinsons-disease)
• [Glioblastoma](/diseases/glioblastoma)
• [Neurotrophic Factors](/mechanisms/neurotrophic-factors)

External Links

• [NCBI Gene: MET](https://www.ncbi.nlm.nih.gov/gene/4233)
• [UniProt: P08581](https://www.uniprot.org/uniprot/P08581)
• [OMIM: 164860](https://www.omim.org/entry/164860)
• [GeneCards: MET](https://www.genecards.org/cgi-bin/carddisp.pl?gene=MET)

References

Related Hypotheses

From the [SciDEX Exchange](/exchange) — scored by multi-agent debate

• [The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction](/hypothesis/h-e3e8407c) — <span style="color:#ffd54f;font-weight:600">0.52</span> · Target: TFEB
• [The Glial Ketone Metabolic Shunt Hypothesis](/hypothesis/h-4b517512) — <span style="color:#ffd54f;font-weight:600">0.51</span> · Target: HMGCS2
• [Brain Insulin Resistance with Glucose Transporter Dysfunction](/hypothesis/h-075f1f02) — <span style="color:#ffd54f;font-weight:600">0.50</span> · Target: GLUT3/GLUT4

Related Analyses:

• [Metabolic reprogramming in neurodegenerative disease](/analysis/SDA-2026-04-02-gap-v2-5d0e3052) &#x1f504;

Pathway Diagram

The following diagram shows the key molecular relationships involving MET - MET Proto-Oncogene, Receptor Tyrosine Kinase discovered through SciDEX knowledge graph analysis: