NETO1 is a human gene whose product nETO2 (Neuropilin and Tolloid Like 2) is a transmembrane protein that plays important roles in synaptic function, neurodevelopment, and cell signaling. It is highly expressed in the central nervous system and participates in the regulation of glutamate receptor trafficking and synaptic plasticity["@little2010"]. Variants in NETO1 have been implicated in Epilepsy, Alzheimer's Disease, Huntington's Disease. This page covers the gene's normal function, disease associations, expression patterns, and key research findings relevant to neurodegeneration.
NETO1 is a human gene whose product nETO2 (Neuropilin and Tolloid Like 2) is a transmembrane protein that plays important roles in synaptic function, neurodevelopment, and cell signaling. It is highly expressed in the central nervous system and participates in the regulation of glutamate receptor trafficking and synaptic plasticity["@little2010"]. Variants in NETO1 have been implicated in Epilepsy, Alzheimer's Disease, Huntington's Disease. This page covers the gene's normal function, disease associations, expression patterns, and key research findings relevant to neurodegeneration.
NETO2 (Neuropilin and Tolloid Like 2) is a transmembrane protein that plays important roles in synaptic function, neurodevelopment, and cell signaling. It is highly expressed in the central nervous system and participates in the regulation of glutamate receptor trafficking and synaptic plasticity[@little2010].
Structure
NETO2 contains:
Two CUB domains (Complement C1r/C1s, Uegf, Bmp1) in the extracellular region