PDGFB — Platelet Derived Growth Factor Subunit B
Overview
flowchart TD
PDGFB["PDGFB"] -->|"associated with"| Primary_Familial_Brain_Calcifi["Primary Familial Brain Calcification"]
PDGFB["PDGFB"] -->|"causes"| Primary_Familial_Brain_Calcifi["Primary Familial Brain Calcification"]
PDGFB["PDGFB"] -->|"causes"| Basal_Ganglia_Calcifications["Basal Ganglia Calcifications"]
PDGFB["PDGFB"] -->|"risk factor for"| Fahr_s_Disease["Fahr's Disease"]
PDGFB["PDGFB"] -->|"modulates"| neurovascular_unit["neurovascular unit"]
PDGFB["PDGFB"] -->|"associated with"| Aging["Aging"]
PDGFB["PDGFB"] -->|"associated with"| Ms["Ms"]
PDGFB["PDGFB"] -->|"associated with"| Parkinson["Parkinson"]
PDGFB["PDGFB"] -->|"associated with"| Als["Als"]
PDGFB["PDGFB"] -->|"regulates"| Ms["Ms"]
PDGFB["PDGFB"] -->|"inhibits"| Ms["Ms"]
PDGFB["PDGFB"] -->|"expressed in"| Fibrosis["Fibrosis"]
PDGFB["PDGFB"] -->|"expressed in"| Als["Als"]
PDGFB["PDGFB"] -->|"activates"| Als["Als"]
style PDGFB fill:#4fc3f7,stroke:#333,color:#000
Pdgfb — Platelet Derived Growth Factor Subunit B plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
...PDGFB — Platelet Derived Growth Factor Subunit B
Overview
Mermaid diagram (expand to render)
Pdgfb — Platelet Derived Growth Factor Subunit B plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Pdgfb — Platelet Derived Growth Factor Subunit B is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@peng2018]
<div class="infobox infobox-gene"> [@zhu2019]
<table>
<tr><th colspan="2" style="background:#e8f4f8; text-align:center; font-size:1.1em;">Platelet Derived Growth Factor Subunit B</th></tr>
<tr><td><strong>Gene Symbol</strong></td><td>PDGFB</td></tr>
<tr><td><strong>Full Name</strong></td><td>Platelet Derived Growth Factor Subunit B</td></tr>
<tr><td><strong>Chromosome</strong></td><td>22q13</td></tr>
<tr><td><strong>NCBI Gene ID</strong></td><td>[5155](https://www.ncbi.nlm.nih.gov/gene/5155)</td></tr>
<tr><td><strong>OMIM</strong></td><td>190040</td></tr>
<tr><td><strong>Ensembl ID</strong></td><td>ENSG00000127314</td></tr>
<tr><td><strong>UniProt ID</strong></td><td>[P01127](https://www.uniprot.org/uniprot/P01127)</td></tr>
<tr><td><strong>Associated Diseases</strong></td><td>Parkinson's Disease, Alzheimer's Disease, Brain Arteriovenous Malformation</td></tr>
</table>
</div>
Function
PDGFB encodes the B chain of platelet-derived growth factor, which can form homodimers (PDGF-BB) or heterodimers (PDGF-AB) with the A chain. PDGF-BB signals through both PDGFRA and PDGFRB, making it a more potent mitogen. In the nervous system, PDGF-B is critical for development of blood vessels, [pericytes](/entities/pericytes), and mesangial cells. It also supports neuronal survival and oligodendrocyte precursor proliferation. PDGF-BB has been studied for its neuroprotective properties in Parkinson's disease models and may promote repair in neurodegenerative conditions. Imbalanced PDGF signaling is implicated in various neurological disorders.
Expression
PDGFB is expressed in:
- Endothelial cells
- Platelets
- Brain ([neurons](/entities/neurons), astrocytes)
- Smooth muscle cells
- Pericytes
Critical for vascular development and maintenance in the brain.
Disease Associations
| Disease | Role | Mechanism |
|---------|------|-----------|
| Alzheimer's Disease | Risk/Progression | Various mechanisms depending on gene function |
| Parkinson's Disease | Risk/Progression | Various mechanisms depending on gene function |
| Amyotrophic Lateral Sclerosis | Risk/Progression | Various mechanisms depending on gene function |
Therapeutic Implications
Targeting PDGFB has therapeutic potential in neurodegenerative diseases through:
- Gene therapy approaches for loss-of-function variants
- Small molecule modulators of protein function
- Protein supplementation strategies
Key Publications
Heldin CH, et al. (2002). "PDGF in development and disease." APMIS. PMID: 12076221(https://pubmed.ncbi.nlm.nih.gov/12076221/)
Sakakibara A, et al. (2019). "PDGF in brain development." Dev Growth Differ. PMID: 31066147(https://pubmed.ncbi.nlm.nih.gov/31066147/)
Peng J, et al. (2018). "PDGFB in Parkinson's disease therapy." Mol Ther. PMID: 29551643(https://pubmed.ncbi.nlm.nih.gov/29551643/)
Zhu W, et al. (2019). "PDGF and [blood-brain barrier](/entities/blood-brain-barrier)." J Cereb Blood Flow Metab. PMID: 31138066(https://pubmed.ncbi.nlm.nih.gov/31138066/)See Also
- [Autophagy](/mechanisms/autophagy)
- [Axonal Transport](/mechanisms/axonal-transport)
- [Amyotrophic Lateral Sclerosis](/diseases/amyotrophic-lateral-sclerosis)
- [Alzheimer's Disease](/diseases/alzheimers-disease)
- [Parkinson's Disease](/diseases/parkinsons-disease)
Overview
Pdgfb — Platelet Derived Growth Factor Subunit B plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Background
The study of Pdgfb — Platelet Derived Growth Factor Subunit B has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
External Links
- [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
- [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
- [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data
References
[Sakakibara A, et al, (2019) (2019)](https://pubmed.ncbi.nlm.nih.gov/31066147/)
[Peng J, et al, (2018) (2018)](https://pubmed.ncbi.nlm.nih.gov/29551643/)
[Zhu W, et al, (2019) (2019)](https://pubmed.ncbi.nlm.nih.gov/31138066/)Pathway Diagram
The following diagram shows the key molecular relationships involving PDGFB — Platelet Derived Growth Factor Subunit B discovered through SciDEX knowledge graph analysis:
Mermaid diagram (expand to render)