PILRB Gene

PILRB Gene

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">PILRB Gene</th>
</tr>
<tr>
<td class="label">Gene Symbol</td>
<td>PILRB</td>
</tr>
<tr>
<td class="label">Gene Name</td>
<td>Paired Immunoglobulin-like Type 2 Receptor Beta</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>7q22.1</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>29998</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>Q9Y5U4</td>
</tr>
<tr>
<td class="label">Gene Type</td>
<td>Protein Coding</td>
</tr>
<tr>
<td class="label">Disease</td>
<td>Evidence Level</td>
</tr>
<tr>
<td class="label">Alzheimer's Disease</td>
<td>Moderate</td>
</tr>
<tr>
<td class="label">Parkinson's Disease</td>
<td>Moderate</td>
</tr>
<tr>
<td class="label">Multiple Sclerosis</td>
<td>Moderate</td>
</tr>
<tr>
<td class="label">Viral infections</td>
<td>Confirmed</td>
</tr>
<tr>
<td class="label">Protein</td>
<td>Interaction Type</td>
</tr>
<tr>
<td class="label">ITIM effectors</td>
<td>Phosphatases</td>
</tr>
<tr>
<td class="label">NK cell receptors</td>
<td>Regulation</td>
</tr>
<tr>
<td class="label">Cytoskeletal proteins</td>
<td>Intracellular</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/alzheimer" style="color:#ef9a9a">Alzheimer</a>, <a href="/wiki/dementia" style="color:#ef9a9a">Dementia</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</

PILRB Gene

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">PILRB Gene</th>
</tr>
<tr>
<td class="label">Gene Symbol</td>
<td>PILRB</td>
</tr>
<tr>
<td class="label">Gene Name</td>
<td>Paired Immunoglobulin-like Type 2 Receptor Beta</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>7q22.1</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>29998</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>Q9Y5U4</td>
</tr>
<tr>
<td class="label">Gene Type</td>
<td>Protein Coding</td>
</tr>
<tr>
<td class="label">Disease</td>
<td>Evidence Level</td>
</tr>
<tr>
<td class="label">Alzheimer's Disease</td>
<td>Moderate</td>
</tr>
<tr>
<td class="label">Parkinson's Disease</td>
<td>Moderate</td>
</tr>
<tr>
<td class="label">Multiple Sclerosis</td>
<td>Moderate</td>
</tr>
<tr>
<td class="label">Viral infections</td>
<td>Confirmed</td>
</tr>
<tr>
<td class="label">Protein</td>
<td>Interaction Type</td>
</tr>
<tr>
<td class="label">ITIM effectors</td>
<td>Phosphatases</td>
</tr>
<tr>
<td class="label">NK cell receptors</td>
<td>Regulation</td>
</tr>
<tr>
<td class="label">Cytoskeletal proteins</td>
<td>Intracellular</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/alzheimer" style="color:#ef9a9a">Alzheimer</a>, <a href="/wiki/dementia" style="color:#ef9a9a">Dementia</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">14 edges</a></td>
</tr>
</table>

Overview

PILRB (Paired Immunoglobulin-like Type 2 Receptor Beta) encodes a membrane protein involved in immune cell signaling. While primarily studied in natural killer cells and macrophages, PILRB has emerging roles in neuroinflammation and neurodegenerative disease pathogenesis["@satoh2006"].

Gene Information

Protein Structure

PILRB contains several key structural features:

• Ig-like domains: Two immunoglobulin-like domains for receptor binding
• Transmembrane region: Single pass membrane-spanning domain
• ITIM motifs: Immunoreceptor tyrosine-based inhibition motifs in cytoplasmic tail

Biological Functions

PILRB performs important immune regulatory functions:

Expression Pattern

PILRB is expressed primarily in immune cells:

• Natural killer cells: High expression on NK cell surfaces
• Macrophages: Modulates phagocytic activity
• Dendritic cells: Regulates antigen presentation
• Brain: Microglial expression

Role in Neurodegeneration

PILRB contributes to neurodegenerative diseases through neuroinflammatory mechanisms:

Microglial Activation

PILRB influences brain immune cell function:

• Regulates microglial activation states
• Modulates inflammatory responses to injury
• Affects cytokine and chemokine production
• Controls phagocytic clearance mechanisms

Immune-Brain Interaction

The receptor mediates crosstalk between peripheral immune system and brain:

• Peripheral immune to brain communication pathways
• Inflammatory signaling across the [blood-brain barrier](/entities/blood-brain-barrier)
• Clearance mechanisms for pathological proteins

Alzheimer's Disease

PILRB may contribute to AD pathogenesis through:

• Modulation of microglial responses to [amyloid-beta](/proteins/amyloid-beta)
• Regulation of chronic neuroinflammation
• Potential effects on [tau](/proteins/tau) pathology

Parkinson's Disease

In PD:

• Regulation of dopaminergic neuron-immune interactions
• Microglial activation in substantia nigra
• Neuroinflammation in disease progression

Disease Associations

Interacting Partners

PILRB interacts with several signaling proteins:

Therapeutic Potential

PILRB offers several therapeutic opportunities:

See Also

• [Neuroinflammation](/mechanisms/neuroinflammation) - Brain inflammation
• [Microglia](/cell-types/microglia) - Brain immune cells
• [Alzheimer's Disease](/diseases/alzheimers-disease) - AD overview
• [Parkinson's Disease](/diseases/parkinsons-disease) - PD overview

External Links

• [NCBI Gene - PILRB](https://www.ncbi.nlm.nih.gov/gene/29998)
• [UniProt - Q9Y5U4](https://www.uniprot.org/uniprot/Q9Y5U4)

References

Pathway Diagram

The following diagram shows the key molecular relationships involving PILRB Gene discovered through SciDEX knowledge graph analysis: