Plaa Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Plaa Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@ref1995a]
<div class="infobox infobox-gene"> [@ref1999]
PLAA [@ref1997]
Phospholipase A2 Activating Protein
| | | [@ref2007] |---|---| [@ref2009] | Symbol | PLAA | | Full Name | Phospholipase A2 Activating Protein | | Chromosome | 9p21.2 | | NCBI Gene ID | [9379](https://www.ncbi.nlm.nih.gov/gene/9379) | | OMIM | [603933](https://www.omim.org/entry/603933) | | Ensembl ID | [ENSG00000137070](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137070) | | UniProt ID | [Q9NSC7](https://www.uniprot.org/uniprot/Q9NSC7) | | Encoded Protein | [PLAA](/proteins/plaa-protein) | | Associated Diseases | [Neurodegeneration](/diseases/neurodegeneration), [Alzheimer's Disease](/diseases/alzheimers-disease), [Inflammatory Diseases](/diseases/neuroinflammation) |
</div>
Function
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PLAA Gene
Overview
Plaa Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Plaa Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@ref1995a]
<div class="infobox infobox-gene"> [@ref1999]
PLAA [@ref1997]
Phospholipase A2 Activating Protein
| | | [@ref2007] |---|---| [@ref2009] | Symbol | PLAA | | Full Name | Phospholipase A2 Activating Protein | | Chromosome | 9p21.2 | | NCBI Gene ID | [9379](https://www.ncbi.nlm.nih.gov/gene/9379) | | OMIM | [603933](https://www.omim.org/entry/603933) | | Ensembl ID | [ENSG00000137070](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137070) | | UniProt ID | [Q9NSC7](https://www.uniprot.org/uniprot/Q9NSC7) | | Encoded Protein | [PLAA](/proteins/plaa-protein) | | Associated Diseases | [Neurodegeneration](/diseases/neurodegeneration), [Alzheimer's Disease](/diseases/alzheimers-disease), [Inflammatory Diseases](/diseases/neuroinflammation) |
</div>
Function
The PLAA gene encodes the phospholipase A2 activating protein (PLAA), a ubiquitously expressed protein that plays a critical role in cellular signaling and lipid metabolism. PLAA functions as a co-activator for group IV cytosolic phospholipase A2 (cPLA2), which releases arachidonic acid from membrane phospholipids - the rate-limiting step in eicosanoid biosynthesis.
Beyond its role in lipid signaling, PLAA is involved in protein ubiquitination and degradation through its association with the proteasome regulatory particle. PLAA contains a PFU (PLAA family ubiquitin-binding) domain that allows it to interact with ubiquitin-modified proteins. This function connects PLAA to the [ubiquitin-proteasome system](/mechanisms/ubiquitin-proteasome-system) (UPS), which is crucial for clearing misfolded and aggregated proteins that accumulate in neurodegenerative diseases.
PLAA has been implicated in Alzheimer's disease pathogenesis through its effects on [amyloid-beta](/proteins/amyloid-beta) production and neuroinflammation. The protein also plays roles in ER stress response and [autophagy](/entities/autophagy), both of which are pathways commonly dysregulated in neurodegenerative conditions.
Plaa Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Background
The study of Plaa Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.