PLN encodes phospholamban, a critical regulator of calcium handling in cardiac and skeletal muscle. While primarily studied in cardiovascular disease, calcium dysregulation is a key feature of neurodegenerative diseases, making PLN relevant to neurodegeneration research. [@mattson2007]
Introduction
PLN (Phospholamban) is a small phosphoprotein that regulates the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA). It is predominantly expressed in cardiac and skeletal muscle, but calcium handling mechanisms involving PLN are also important in [neurons](/entities/neurons) where calcium dysregulation is a hallmark of neurodegeneration. [@gleichmann2011]
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title: PLN Gene
PLN (Phospholamban)
Overview
Mermaid diagram (expand to render)
PLN encodes phospholamban, a critical regulator of calcium handling in cardiac and skeletal muscle. While primarily studied in cardiovascular disease, calcium dysregulation is a key feature of neurodegenerative diseases, making PLN relevant to neurodegeneration research. [@mattson2007]
Introduction
PLN (Phospholamban) is a small phosphoprotein that regulates the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA). It is predominantly expressed in cardiac and skeletal muscle, but calcium handling mechanisms involving PLN are also important in [neurons](/entities/neurons) where calcium dysregulation is a hallmark of neurodegeneration. [@gleichmann2011]
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| Property | Value | |----------|-------| | Gene Symbol | PLN | | Full Name | Phospholamban | | Chromosomal Location | 6q22.1 | | NCBI Gene ID | 5350 | | OMIM ID | 172090 | | Ensembl ID | ENSG00000160072 | | UniProt ID | P26678 | | Encoded Protein | Phospholamban | | Associated Diseases | Dilated cardiomyopathy, neurodegenerative diseases (calcium dysregulation), sarcopenia |
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Function
Phospholamban regulates calcium reuptake into the sarcoplasmic reticulum:
In Muscle (Primary Function)
Inhibits SERCA1 (skeletal muscle) and SERCA2 (cardiac muscle)