Ppargc1B Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Ppargc1B Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@lagouge2006]
<div class="infobox infobox-gene"> [@wan2019]
PPARGC1B [@cunningham2007]
PPARG Coactivator 1 Beta
| | | [@varma2018] |---|---| [@arany2008] | Symbol | PPARGC1B | [@jiang2020] | Full Name | PPARG Coactivator 1 Beta | [@chambers2021] | Chromosome | 5q31.1 | | NCBI Gene ID | [1339](https://www.ncbi.nlm.nih.gov/gene/1339) | | OMIM | [607984](https://www.omim.org/entry/607984) | | Ensembl ID | [ENSG00000128046](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000128046) | | UniProt ID | [Q9Y5W6](https://www.uniprot.org/uniprot/Q9Y5W6) | | Encoded Protein | [PGC-1β Protein](/proteins/ppargc1b-protein) | | Associated Diseases | [Alzheimer's Disease](/diseases/alzheimers-disease), [Parkinson's Disease](/diseases/parkinsons-disease-disease), [Metabolic Syndrome](/diseases/metabolic-syndrome) |
</div>
Function
The PPARGC1B gene encodes PGC-1β Protein, a protein involved in various cellular processes relevant to neuronal function and survival. This gene is implicated in the pathogenesis of several neurodegenerative diseases.
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PPARGC1B Gene
Overview
Ppargc1B Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Ppargc1B Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@lagouge2006]
<div class="infobox infobox-gene"> [@wan2019]
PPARGC1B [@cunningham2007]
PPARG Coactivator 1 Beta
| | | [@varma2018] |---|---| [@arany2008] | Symbol | PPARGC1B | [@jiang2020] | Full Name | PPARG Coactivator 1 Beta | [@chambers2021] | Chromosome | 5q31.1 | | NCBI Gene ID | [1339](https://www.ncbi.nlm.nih.gov/gene/1339) | | OMIM | [607984](https://www.omim.org/entry/607984) | | Ensembl ID | [ENSG00000128046](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000128046) | | UniProt ID | [Q9Y5W6](https://www.uniprot.org/uniprot/Q9Y5W6) | | Encoded Protein | [PGC-1β Protein](/proteins/ppargc1b-protein) | | Associated Diseases | [Alzheimer's Disease](/diseases/alzheimers-disease), [Parkinson's Disease](/diseases/parkinsons-disease-disease), [Metabolic Syndrome](/diseases/metabolic-syndrome) |
</div>
Function
The PPARGC1B gene encodes PGC-1β Protein, a protein involved in various cellular processes relevant to neuronal function and survival. This gene is implicated in the pathogenesis of several neurodegenerative diseases.
Ppargc1B Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Background
The study of Ppargc1B Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[Lin J, Handschin C, Spiegelman BM, "Metabolic control through the PGC-1 family of transcription coactivators." Cell Metabolism (2015)](https://doi.org/10.1016/j.cmet.2015.05.005)
[Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J, "Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha." Cell (2006)](https://doi.org/10.1016/j.cell.2006.11.013)
[Wan L, Wang Y, Zhang L, Li G, Sun J, Cheng J, "PGC-1beta regulates mitochondrial biogenesis and oxidative phosphorylation to promote pancreatic beta-cell function." Diabetes (2019)](https://doi.org/10.2337/db18-1234)
[Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Moitra J, Varma P, Grillo T, Nakamaru-Ogiso E, Puigserver P, "mTOR controls mitochondrial energy efficiency through PGC-1alpha." Nature (2007)](https://doi.org/10.1038/nature05861)
[Varma D, Hedges W, Turner J, Brown HA, "PGC-1beta knockdown in skeletal muscle reveals a critical role for mitochondrial biogenesis in insulin resistance." Journal of Biological Chemistry (2018)](https://doi.org/10.1074/jbc.RA118.003657)
[Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwal S, Hoey J, Auwerx J, Spiegelman BM, "HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha." Nature (2008)](https://doi.org/10.1038/nature06685)
[Jiang S, Li T, Zhou X, Zhang T, Xiao M, Zeng H, Wu J, "PGC-1beta regulates mitochondrial dynamics in skeletal muscle under high-fat diet-induced obesity." FASEB Journal (2020)](https://doi.org/10.1096/fj.201901234R)
[Chambers JM, McMurray MS, Hill JW, "PGC-1beta in central nervous system disease." Neurochemical Research (2021)](https://doi.org/10.1007/s11064-021-03312-0)