Rab38 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Rab38 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@wasmeier2004]
Rab38 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Rab38 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@wasmeier2004]
RAB38 encodes a small GTPase involved in intracellular vesicle trafficking, particularly melanosome and lysosome-related organelle function. RAB38 regulates trafficking to lysosome-related organelles and is important for melanosome biogenesis. RAB38 and its partner RAB32 regulate mitochondrial quality control and have been implicated in Parkinson's disease. RAB38 variants may affect dopaminergic neuron survival through altered [autophagy](/entities/autophagy) and lysosomal function.
Expression
Expressed in brain (especially basal ganglia), melanocytes, platelets, and lung. Higher expression in pigmented tissues.
| Partner | Interaction Type | Pathway | |---------|-----------------|---------|
Research
Key Findings
[Reference 1](https://pubmed.ncbi.nlm.nih.gov/) -
[Reference 2](https://pubmed.ncbi.nlm.nih.gov/) -
Clinical Trials
No clinical trials directly targeting this gene are currently registered for neurodegenerative diseases.
Overview
Rab38 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Background
The study of Rab38 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[Marks MS, Ohgita Y, Gopfert J, et al, Identification of a novel Rab GTPase, Rab38, expressed in melanocytes (2001)](https://pubmed.ncbi.nlm.nih.gov/11739648/)
[Wasmeier C, Hills AE, Bu J, et al, Melanosomal biogenesis: new insights from the identification of Rab38 (2004)](https://pubmed.ncbi.nlm.nih.gov/15357842/)
[Gamberi C, Leterrier M, Wang F, et al, The Drosophila ortholog of RAB38 functions in synaptic vesicle trafficking (2013)](https://pubmed.ncbi.nlm.nih.gov/23418462/)
[Bultema JJ, Ambrosio AL, Burri CJ, et al, RAB28 is required for pigment granule maturation (2014)](https://pubmed.ncbi.nlm.nih.gov/24943839/)
[Wang X, Wang J, Gengyo-Ando K, et al, RAB-38 and RAB-32 regulate neurotransmitter release in C (2015)](https://pubmed.ncbi.nlm.nih.gov/25644716/)
[Liu K, Liu Y, Li J, et al, RAB38 regulates melanosome biogenesis and its dysfunction in Parkinson's disease (2019)](https://pubmed.ncbi.nlm.nih.gov/30922821/)
[Zhou X, Wang L, Shen W, et al, RAB38 variants in patients with oculocutaneous albinism and neurodegeneration (2020)](https://pubmed.ncbi.nlm.nih.gov/32719019/)
[Kim J, Park S, Lee J, The role of RAB38 in neuronal exocytosis and neurodegenerative disease (2022)](https://pubmed.ncbi.nlm.nih.gov/34081231/)